牡丹皮化学成分、药理作用及其质量标志物（Q-Marker）的预测分析

牡丹皮首载于《神农本草经》,具有清热凉血、活血化瘀的功效,是临床常用的清热凉血药,其化学成分主要包括苯乙酮类、萜类及其苷类、有机酸类以及其他类成分,具有抗炎、调节免疫功能、保护心血管等作用。通过分析牡丹皮植物亲缘学、化学成分特有性证据、化学成分可测性等的关系,对牡丹皮的质量标志物（quality marker,Q-Marker）进行分析,并预测丹皮酚、芍药苷、没食子酸、苯甲酰芍药苷、苯甲酰氧化芍药苷、氧化芍药苷、1,2,3,4,6-O-五没食子酰葡萄糖、丹皮酚原苷、丹皮酚新苷、牡丹皮苷C、苯甲酸等可作为其Q-Markers,以期为牡丹皮质量评价体系的建立提供参考。

Chemical constituents, pharmacological effects of Moutan Cortex and predictive analysis on its quality marker (Q-Marker)

Mudanpi (Moutan Cortex) was first recorded in "Shen Nong''s Materia Medica". It has the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis. It is a commonly used clinical medicine for clearing heat and cooling blood. Its chemical components mainly include acetophenones, terpenes and their glycosides, organic acids and other components, which have anti-inflammatory, immune function, and cardiovascular protection effects. By analyzing the relationship between plant genetics, chemical composition specificity evidence, chemical composition measurability, etc., the quality markers (Q-Markers) of Moutan Cortex were analyzed from various aspects, and the prediction of paeonol, paeoniflorin, gallic acid, benzoylpaeoniflorin, benzoyloxypaeoniflorin, oxypaeoniflorin, 1,2,3,4,6-O-pentagalloylglucose, paeonolide, apiopaeonoside, mudanpioside C, benzoic acid etc. can be used as its Q-Markers, in order to provide a reference for the establishment of quality evaluation system of Moutan Cortex.