Morphologic characteristics of aortic atresia: implications for fetal hemodynamics |
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| Authors: | J A Hawkins E B Clark D B Doty |
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| Affiliation: | 1. Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi''an 710032, China;2. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi''an 710069, China;3. Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi''an 710038, China;4. Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, 1 Xinsi Road, Xi''an 710038, China;5. Department of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi''an 710032, China;2. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States;3. Departments of Anesthesiology & Pain Medicine, Pharmacology, and Pediatrics, Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada;4. Departments of Obstetrics and Gynecology and Physiology, Women and Children’s Health Research Institute, University of Alberta, Edmonton, AB, Canada;1. Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U 1217, Institut NeuroMyoGene, F-69622 Villeurbanne, France;2. CNRS UMR 5239, Laboratoire de Biologie Moléculaire de la Cellule, ENS Lyon, 46 Allée d''Italie, 69364 Lyon cedex 07, France;3. CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France;4. Neuromuscular Research Center, Departments of Neurology and Biomedicine, Pharmazentrum, Basel University Hospital, 4056 Basel, Switzerland;5. INRA, UMR866 Dynamique Musculaire et Métabolisme, Université Montpellier 1, F 34060 Montpellier, France;6. INSERM UMR-1060, Laboratoire CarMeN, Université Lyon 1, Faculté de medicine, Rockefeller et Charles Merieux Lyon-Sud, Lyon 69003, France;7. INRA, UMR 1019, UNH, CRNH, F-63000, Auvergne, Clermont-Ferrand, France;8. Hospices Civils de Lyon, Service d''Anatomie et Cytologie Pathologiques, Hôpital Édouard Herriot, France |
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| Abstract: | ![]()
We studied hearts with aortic atresia to determine the relationship between cardiac morphology and fetal cardiac blood flow. We compared measurements of aortic, pulmonary, and tricuspid valve circumference and right ventricular wall thickness among 37 hearts with aortic atresia and mitral hypoplasia, 14 hearts with aortic atresia together with mitral atresia and 24 normal hearts. Right ventricular free wall thickness and tricuspid and pulmonary valve annular circumferences were greater and aortic circumferences were smaller in hearts with aortic atresia than in normal hearts (P less than 0.05). Between the subgroups of aortic atresia, the aortic circumference was 5 +/- 1 mm in those with mitral atresia compared to 7 +/- 2 mm in association with mitral hypoplasia (P less than 0.05). The morphologic differences between the subgroups of aortic atresia are consistent with differences in fetal blood flow. Left heart blood flow was likely to be greater during development in those hearts with aortic atresia and mitral hypoplasia than in those with the combination of aortic and mitral atresia. |
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