Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile,cardiomyocytes structure,and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting |
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| Authors: | Marlieke Visser Mariska Davids Hein J Verberne Wouter EM Kok Hans WM Niessen Lenny MW van Venrooij Riccardo Cocchieri Willem Wisselink Bas AJM de Mol Paul AM van Leeuwen |
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| Affiliation: | (1) Department of Cardiothoracic Surgery, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands;(2) Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands;(3) Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands;(4) Department of Nuclear Medicine, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands;(5) Department of Cardiology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands;(6) Department of Pathology and Cardiac Surgery, VU University Medical Center, Amsterdam, The Netherlands;(7) iCaR-VU, VU University Medical Center, Amsterdam, The Netherlands |
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| Abstract: | ![]()
Background Malnutrition is very common in patients undergoing cardiac surgery. Malnutrition can change myocardial substrate utilization which can induce adverse effects on myocardial metabolism and function. We aim to investigate the hypothesis that there is a disturbed amino acids profile in the cardiac surgical patient which can be normalized by (par)enteral nutrition before, during and after surgery, subsequently improving cardiomyocyte structure, cardiac perfusion and glucose metabolism. |
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