女性泌尿生殖道支原体感染及耐药性分析

目的通过分析本院2008年女性泌尿生殖道解脲脲支原体(Uu)和人型支原体(Mh)感染状况及耐药性变迁,为临床提供最新的流行病学资料及用药指导。方法采用法国生物梅里埃公司Mycoplasma IST2支原体鉴定及药敏试剂盒,检测本院妇产科送检的女性泌尿生殖道分泌物,分析支原体培养和药敏试验结果等资料。结果 1041例患者总检出率58.6%(610/1041),其中Uu阳性519例(49.9%);Mh阳性10例(1%);Uu+Mh阳性81例(7.8%)。610例患者支原体对9种抗生素敏感性依次为原始霉素(99.8%)、交沙霉素(99.5%)、强力霉素(96.1%)、四环素(93.4%)、克拉霉素(83.8%)、阿奇霉素(75.9%)、红霉素(73.4%)、氧氟沙星(27.9%)和环丙沙星(21.8%)。结论支原体(尤其是Uu)感染已成为女性泌尿生殖系统炎性反应的主要病原体之一,且耐药性变异十分明显,治疗支原体感染应选择原始霉素、交沙霉素、强力霉素等敏感率高的药物及药敏试验显示敏感的药物,喹诺酮类药物耐药率较高,应引起临床重视。

Analyze the infection and drug resistance of Mycoplasma among female urogenital tract

Objective To analyze the infection and drug resistance of Ureaplasma urealyticum (Uu) and mycoplasma hominis ( Mh) among female urogenital tract in 2008,hope to provide the data of epidemiology and guide of antibiotics use.Methods Cervical secretion was identified and their antibiotic susceptibility was detected with Mycoplasma IST 2 Reagent from France,the result of mycoplasma cultivation and the sensitivities to antibiotics was analyzed.Results The positive rate of Mycoplasma was 58.6%(610/1 041),among the the 610 positive sample,519(49.9%) cases were Uu positive; 10 cases(1%)were Mh positive;81 ca-ses(7.8%)vrere both Uu and Mh positive;the susceptibility to all these 9 antimicrobial agents in sequence wase Pristinamycin(99.8%)、 Josamycin(99.5%),Doxycycline(96.1 % )、Tetracycline(93.4%) 、Clarithromycin(83.8%)、 Azithromycin(75.9%)、Erythro-mycin(73.4%)、Ofloxacin(27.9%) and Ciprofloxacin(21.8%).Conclusion Mycoplasma (especially Uu) was the main pathogen of urogenital tracts among female with great variation of susceptibility to antibiotics.The sensitive antibiotics should be used to treat the infection of Uu and Mh,such as Pristinamycin,Josamycin,Doxycycline.But Mycoplasma have a high resistance rate to quinolones,that should be paid more attention.