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| 国产盐酸格拉司琼注射液止吐作用的评价 | |
| 引用本文： | 殷凯生,解卫平,祝浩强,钱志英,胡岳隶,凌杨,徐随福,杨宁蓉. 国产盐酸格拉司琼注射液止吐作用的评价[J]. 中国癌症杂志, 2000, 10(2): 121-123 |
| 作者姓名： | 殷凯生 解卫平 祝浩强 钱志英 胡岳隶 凌杨 徐随福 杨宁蓉 |
| 作者单位： | 1. 南京医科大学第一附属医院,江苏,南京210029 2. 江苏省肿瘤医院 3. 常州市肿瘤医院 4. 解放军八一医院 |
| 摘 要： | 目的：为了评价国产盐酸格拉司琼注射液止吐疗效及安全性。方法：在１０６例肿瘤病人中以灭吐灵和进口格拉司琼注射液为对照药作了自身对比的交叉研究。结果：（１）国产与进口格拉司琼临床止吐有效率（分别为８６．８％和８６．６％）与不良反应发生率（分别为２３．５％和２９．４％）均相似（Ｐ〉０．０５）；（２）国产格拉司琼止吐有效率显著高于对照药灭吐灵的止吐有效率（５０．０％，Ｐ〈０．０１），两者不良反应发生率差异 |
| 关 键 词： | 盐酸格拉司琼 止吐 有效性 安全性 |
| 文章编号： | 1007-3639(2000)02-0121-03 |
| 修稿时间： | 1998-12-26 |
A study on antiemetic efficacy of domestic granisetron injection |
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| YIN Kai sheng,XIE Wei Ping,ZHU Hao qiang,et al.. A study on antiemetic efficacy of domestic granisetron injection[J]. China Oncology, 2000, 10(2): 121-123 | |
| Authors: | YIN Kai sheng XIE Wei Ping ZHU Hao qiang et al. |
| Abstract: | Purpose:To evaluate the antiemetic efficacy and safety of domestic granisetron injection. Methods:We compared it with Metoclopramidum injection or imported Granisetron injection in 106 patients with cancer using the method of self crossover study. Results:It is shown that (1) the domestic and imported Granisetron had similar antiemitic efficacy (86.8% V 86.6%) and side effective rate (23.5% V 29.4%);(2) the effective rate of domestic Granisetron (86.8%) was significantly higher than that of Metoclopramidum (50.0%, P <0 001), and there was no significant difference in Metoclopramidum (50.0%, P <0 001),and there was no significant difference in side effect rates between Granisetron and Metoclopramidium.Conclusions:The domestic Granisetron injection is an effective and safe antiemetic drug. |
| Keywords: | granisetron antiemesis treatment effecacy safety |
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