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In vitro myelin basic protein synthesis in the PNS and CNS of myelin deficient (mld) mutant mice |
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| Authors: | Helga Ginalski-Winkelmann Guillermina Almazan Jean-Marie Matthieu |
| Affiliation: | Laboratoire de Neurophysiologie, Département de Physiologie, Facultéde Médecine, UniversitéLaval, Québec G1K 7P4 Canada |
| Abstract: | The CNS of the mutant mld has a severe myelin deficit. In contrast, myelination is normal in the PNS. Previous studies showed that myelin basic proteins (MBP) are practically missing in mld CNS and PNS tissues. Using an in vitro system and immunoprecipitation, we present evidence that MBP synthesis is repressed in the PNS and in the CNS of mld mutants. |
| Keywords: | myelin basic protein hypomyelination central nervous system myelin peripheral nervous system myelin mld mutant mouse |
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