首发精神分裂症的认知功能与阴,阳性症状和抗精神病药物效应的关系

目的 探讨首发精神分裂症认知功能与阴、阳性症状和抗精神病药物效应的关系。方法 对７８例精神分裂症患者给予氯丙嗪或氯氮平治疗，于治疗前及治疗１２周末各作一次Ｗｉｓｃｏｎｓｉｎ卡片分类测验（ＷＣＳＴ）、韦氏成人智力量表（ＷＡＩＳＲ）、韦氏记忆量表（ＷＭＳ）、语言流利性测验等。另外，４５例正常人也做了上述测验。结果 首发精神分裂症患者存在广泛的认知功能障碍，上述则查结果均较正常对照组差，尤以ＷＣＳＴ明显

Relationships of cognitive function,positive or negative symptoms,and response to antipsychotic in first-episode schizophrenic patients

Objective To assess the changes in cognitive function for first-episode schizophrenia and positive or negative symptoms and antipsychotic efficacy.Methods Seventy-eight first-episode schizophrenic patients were treated with chlorpromazine or clozapine.Cognitive function of all patients were assessed with Wisconsin Card Sorting Test(WCST),WAIS-R,WMS and Language Fluency Test before and twelve weeks after treatment.Results Extensive cognitive function impairment had been observed in first-episode schizophrenia.All cognitive results of patients were poorer than those of controls.Especially the performance of WCST,and it were not related to positive symptoms.Improvement of negative symptoms may be helpful to changes of cognition,but cognition were not of full equal rank efficacy,it also wasn't related fo EEG results.Conclusion Cognition disorder may be intrinsic symptoms of first- episode schizophrenia.The changes of cognitive function wer not of equal rank improvement of positive symptoms.