奥美拉唑治疗老年人反流性食管炎的临床观察

目的　研究奥美拉唑 (Omeprazole ,简称Ome)对我国老年人反流性食管炎的疗效。方法　Ome2 0mg晨服 ,服药 8周。结果　临床总有效率 10 0 % ,内镜下愈合率 93.3% ;内镜证实愈合的患者 ,停药 2月、6月、12月累积复发率分别为 6 0 .5 %、81.4%和 90 .7%。结论　Ome对老年人反流性食管炎的近期及维持治疗均有良好疗效 ,但停药后复发率高 ,需维持治疗。

Clinical observation on omeprazole in treating reflux esophagitis in the aged

Objective To study the efficacy of omeprazole for therapy of reflux esophagitis in the aged. Methods the patients were treated with omeprazole of 20mg daily, continuously for 8 weeks. Results The clinical total effective rate was 100%, The endoscopic healing rate was 93.3%. 43 cases of healing patients stopped omeprazole treatment, their cumulative recurrent rates at 2,6,12, months were 60.5%,81.4%and 90.7% respectively. Conclusions The results showed that efficacy of omeprazole in short term and maintaining treatment for the elderly reflux esophagitis was ideal. The adverse reactions of omeprazole were slight. But recurrent rate was very high after stopping treatment, as compared with other therapies. Therefore, maintaining treatment is required in many patients.