急性心肌缺血时锌铜含量的变化及影响

目的　探讨急性心肌缺血时锌铜含量的变化及影响。方法　分别测定急性心肌缺血家兔局部心肌、心血、外周血及 15 0例急性心肌缺血病人血清中锌铜含量 ,并与对照组比较。腹腔给予急性心肌缺血家兔补充锌铜溶液 ,观察给予前后ECG变化。结果　家兔随心肌缺血时间延长 ,锌铜含量在局部心肌中逐渐减少 ,心血及外周血中逐渐增加 ,与对照组比差异显著 (P <0 .0 5 ) ;急性心肌缺血病人血清锌铜含量明显降低 (P <0 .0 1) ;家兔腹腔给予锌铜溶液心肌缺血及心律失常明显好转。结论　急性心肌缺血早期锌铜含量变化能引起心电活动的改变 ,可能是猝死的原因之一。补充锌铜对纠正心律失常及心肌缺血有一定作用。

Change and influence of content of zinc and copper in acute myocardial ischemic

Objective To probe into change and influence of content of zinc and copper in acute myocardial ischemic. Methods We measure respectively content of zinc and copper of part myocardial muscle and heart cavity blood and vine blood with acute myocardial ischemic of rabbits and content of serum zinc and copper with acute myocardial ischemic patients of 150 cases. ECG change was observed after supplementation zinc and copper of abdomen cavity in rabbits of acute myocardial ischemic. Results With the prolonged ischemic time zinc and copper content in ischemic myocardium of rabbits tended to reduce and to increase heart blood and vine blood. It was significant ( P <0.05) between the experimental group and the control group; ischemic myocardial muscle and arrhythmia took a favourable turn with injecting zinc and copper into abdomen cavity of rabbits. Conclusions Changes of zinc and copper content in early acute myocardial ischemic give rise to abnormal heart activity. It is a cause of sudden death. Complement zinc and copper have certain effect of corrected arrhythemia and myocardial ischemic.