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人大肠癌组织血管内皮生长因子C及血管内皮细胞生长因子受体3和P53蛋白的表达及临床意义
引用本文:贺生,刘安丽,张庆远,王海鑫,徐国昌. 人大肠癌组织血管内皮生长因子C及血管内皮细胞生长因子受体3和P53蛋白的表达及临床意义[J]. 中国医药, 2013, 8(10): 1425-1427
作者姓名:贺生  刘安丽  张庆远  王海鑫  徐国昌
作者单位:1. 473058,南阳医学高等专科学校科研处
2. 南阳医学高等专科学校第一附属医院病理科
3. 473058,南阳医学高等专科学校流行病学教研室
基金项目:河南省教育厅自然科学研究计划项目
摘    要:
目的研究血管内皮生长因子(VEGF)C及血管内皮生长因子受体(VEGFR)3和P53蛋白在大肠癌组织中的表达及其与临床病理和预后的关系。方法对89例大肠癌患者手术切除标本的癌组织、癌旁组织及正常大肠组织采用免疫组织化学方法检测VEGF—C、VEGFR-3和P53蛋白表达情况,分析其变化规律。结果VEGF—C、VEGFRG和P53在大肠癌组织中的阳性表达高于癌旁组织及正常大肠组织,差异有统计学意义[癌组织:67.4%(60/89)、55.1%(49/89)和66.3%(59/89),癌旁组织:22.6%(12/53)、20.8%(11/53)、11.3%(6/53),正常组织:13.2%(7/53)、11.3%(6/53)、0,P〈0.05]。DukesB、C和D期的大肠癌P53阳性率[分别为:61.1%(11/18)、76.2%(16/21)、87.1%(27/31)]均高于DukesA期[26.3%(5/19)],差异均有统计学意义(均P〈0.05);DukesD期高于DukesB期(P〈0.05)。大肠高分化腺癌P53阳性率低于中分化和低分化腺癌,差异均有统计学意义[45.7%(16/35)比78.3%(18/23)、81.1%(25/31),P〈0.05],中分化腺癌与低分化腺癌P53阳性率的差异无统计学意义(P〉0.05)。89例大肠癌中60例有淋巴结转移,VEGF—C和VEGFR-3阳性率分别为76.7%(46例)和63.3%(38例);无淋巴结转移者29例,VEGF-C和VEGFRG阳性率分别为48.3%(14例)和37.9%(11例);有淋巴结转移患者中VEGF—C和VEGFR-3阳性率明显高于无淋巴结转移者(P〈0.05)。VEGF—C在黏膜下层、肌层和浆膜层的阳性率分别为50.0%(12/24)、67.6%(25/37)和82.1%(23/28),黏膜下层阳性率与浆膜层的差异有统计学意义(P〈0.05);VEGFR-3的阳性率分别为29.2%(7/24)、54.1%(20/37)和78.6%(22/28),浆膜层阳性表达率高于黏膜下层和肌层,差异有统计学意义(P〈0.05)。在大肠低、中、高分化腺癌组织中VEGF—C阳性率分别为83.9%(26/31)、69.6%(16/23)、51.4%(18/35),VEGFR-3阳性率分别为77.4%(24/31)、56.5%(13/23)、34.3%(12/35),VEGF-C和VEGFR-3在低分化程度阳性表达率高于高分化程度者,差异有统计学意义(P〈0.05)。结论大癌组织中VEGF—C及VEGFR~、P53的表达可能是肿瘤发生、浸润、转移的重要因素,联合检测对判断肿瘤的恶性程度、转移、预后、评价复发具有重要的临床意义。

关 键 词:大肠癌  血管内皮生长因子  P53蛋白

Expression of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 and P53 in human colorectal carcinoma
HE Sheng , LIU An-li , ZHANG Qing-yuan , WANG Hai-xin , XU Guo-chang. Expression of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 and P53 in human colorectal carcinoma[J]. China Medicine, 2013, 8(10): 1425-1427
Authors:HE Sheng    LIU An-li    ZHANG Qing-yuan    WANG Hai-xin    XU Guo-chang
Affiliation:HE Sheng , LIU An-li, ZHANG Qing-yuan, WANG Hai-xin, XU Guo-cbang. Department of Research, Nanyang Medical College, Henan Province, Nanyang 473058, China
Abstract:
Objective To observe the expression of vascular endothelial growth factor(VEGF) C and vascular endothelial growth factor receptor(VEGFR)-3, P53 protein in human colorectal carcinom and correlations with clinical pathology and prognosis. Methods Immunohistochemistry technique was used to detect the expression of VEGF-C and receptor VEGFR-3, P53 protein of the carcinoma tissues and normal tissues around the colon. The relation of the expression of these three proteins, together with the clinical pathology and prognosis, was investigated. Results In cancer specimens, the expression of VEGF-C and receptor VEGFR-3, P53 protein were 67.4%, 55.1% and 66.3% ; those in normal colorectal tissue were 13.2% , 11.3% and 0.0% (P 〈0.05). Regarding expression of VEGF-C and receptor VEGFR-3, P53 protein of was not correlated with the size and site of the tumor. However, the expression was significant correlated with the degree of differentiation, Dukes stages, metastasis and recurrence of the colorectal carcinoma. Conclusions VEGF-C, receptor VEGFR-3 and P53 protein may be involved in carcinogenesis development invasion and metastasis, prognosis, relapse of the tumor. P53 protein may be a factor in postoperative chemotherapy selection for patients with coloreetal carcinoma.
Keywords:Colorectal carcinoma  Vascular endothelial growth factor  P53 protein
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