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| 刺五加对大鼠离体心脏缺血再灌心律失常与细胞动作电位的作用 | |
| 引用本文： | 田葆杰,高天礼,宋正亮. 刺五加对大鼠离体心脏缺血再灌心律失常与细胞动作电位的作用[J]. 中国中药杂志, 1989, 14(8): 45-47 |
| 作者姓名： | 田葆杰 高天礼 宋正亮 |
| 作者单位： | 北京大学生物学系生理教研室;北京大学生物学系生理教研室;哈尔滨中药二厂 |
| 摘 要： | 用Langendorff法与微电极技术研究刺五加对大鼠离体心脏缺血再灌心律失常与细胞动作电位的作用。刺五加浸膏(1.2～2.4mg生药/ml)使室颤和室速发生率明显下降,使正常窦律时间增加,并可使异常动作电位显著减少。 |
| 关 键 词： | 刺五加 心律失常 动作电位 |
Effects of Ciwujia(Acanthopanax senticosus Harms) on Reperfusion Induced Arrhythmias and Action Potential Alterations in Isolated Rat Heart |
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| Tian Baojie Gao Tianli. Effects of Ciwujia(Acanthopanax senticosus Harms) on Reperfusion Induced Arrhythmias and Action Potential Alterations in Isolated Rat Heart[J]. China Journal of Chinese Materia Medica, 1989, 14(8): 45-47 | |
| Authors: | Tian Baojie Gao Tianli |
| Abstract: | By means of Langendorff method and standard microelectrode techniques the effects of Ciwujia on roperfusion induced arrhythmias and action potential alterations were studied in isolated rat heart with transient coronary occlusion. Inclusion of Ciwujia extract (equivalent to 1.2 and 2.4 mg crude drug/ml) was found helpful in reducing reperfusion induced ventrieular fibrillation and ventricular tachycardid. Associated with this reduction in rhythm disturbances was an increase in the total duration of normal sinus rhythm during the 3 min reperfusion period. With the administration of Ciwujia the number of cells with abnormal action potential configurations was significantly reduced. This confirms that Ciwujia can protect myocardium from electrophysiological abnormalities, and therefore reduces the incidence of malignant arrhythmias. |
| Keywords: | Ciwujia (Acanthopanax senticosus) ischemia-reperfusion action potential |
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