颈动脉粥样硬化与血清同型半胱氨酸水平变化的关系

目的探讨血清同型半胱氨酸（HCY）水平与颈动脉粥样硬化的相关性。方法选取住院患者90例，采用彩色多普勒超声仪检测颈动脉，根据检测结果分为3组：内膜正常组、内膜增厚组和斑块形成组。用比浊法测定血清HCY浓度，并比较3组之间的差异。结果随着颈动脉粥样硬化程度的加重，血清HCY的浓度也明显地增高，差异有统计学意义（P〈0．05）。血清HCY浓度与颈动脉粥样硬化的程度呈正相关。结论HCY在颈动脉粥样硬化的发生、发展中起重要的作用，血清HCY水平是动脉粥样硬化的一个独立危险因素。

Study of the Relationship between the Serum Homocysteine Level and Carotid Artery Atherosclerosis

Objective To study the correlation between the serum homocysteine (HCY) level and the carotid artery atheroscleresis.Methods A total of 90 patients were included.Carotid intimal-media thickness was measured by colour Doppler ultrasound meter.According to the test results the cases were divided into three groups,as group of normal internal mem- brahe,group of artery intimal thickening and the group of plaque formation.The serum homocysteine level was measured with tur- bidimetry method,and the differences between the three groups were compared.Results With the increased severity of carot- id atheroscleroeis,the level of serum HCY also significantly increased (P<0.05).The serum homocysteine level was poeitively correlated to carotid atheresclerosis extent.Conclusion HCY plays an important role in the generation and development of the carotid atherosclercsis.The serum homocysteine level is an independent risk factor of the carotid atheresclerosis.