慢性丙型肝炎患者混合或重叠感染其他病原体状况分析

目的了解丙型肝炎病毒（HCV）感染者混合或重叠感染乙型肝炎病毒（HBV）、人免疫缺陷病毒（HIV）和梅毒螺旋体（TP）的状况,为HCV感染的防治提供依据。方法采用ELISA法检测乙型肝炎病毒标志物、抗TP和抗HIV;采用化学发光法检测抗HCV;采用蛋白印迹法确认HIV感染。结果在169例HCV感染者中,重叠感染HBV 25例（14.8%）、HIV 4例（2.4%）、TP 9例（5.3%）,重叠感染HBV和TP 2例（1.2%）,重叠感染HBV和HIV 2例（1.2%）;静脉吸毒者重叠感染HIV（6.7%）和TP（11.1%）的比例均明显高于非静脉吸毒者（P〈0.05）;男性患者重叠感染HBV的比例（19.7%）明显高于女性患者（3.8%,P〈0.01）,女性患者重叠感染TP的比例（11.5%）明显高于男性患者（2.6%,P〈0.05）。结论随着感染方式的多元化,慢性丙型肝炎患者重叠感染其他病原体的情况更加常见。

The co-infection of hepatitis B virus,human immunodeficiency virus and treponema pallidum in patients with chronic hepatitis C

Objective To investigate the co-infection of hepatitis B virus,human immunodeficiency virus and treponema pallidum in patients with chronic hepatitis C.Methods HBV markers and anti-TP and preliminary screening of anti-HIV were detected by ELISA,and anti-HCV was detected by chemiluminescence,and western blot was applied to confirm the HIV infection.Results In 169 patients with HCV infection,25(14.8%) had HBsAg,4(2.4%) had anti-HIV,9(5.3%) had anti-TP,2(1.2%) had HBsAg and anti-TP,and 2(1.2%) had HBsAg and anti-HIV positive;The co-infection with HIV(6.7%) and TP(11.1%) in intravenous drug users were higher than those in patients without history of intravenous drug use(P<0.05);The proportion of co-infection with HBV(19.7%) in male patients was higher than that in female patients(3.8%,P<0.01);The proportion of co-infection with TP(11.5%) in female patients was higher than that in male patients(2.6%,P<0.05);The patients older than 40 years were mainly co-infected with HBV(20.9%),and the proportions of co-infection with HIV(3.9%) and TP(7.8%) increased significantly in the younger patients.Conclusions It is not uncommon in patients with chronic hepatitis C co-infected with other blood-borne pathogens.