EV71所致手足口病70例临床分析

目的 探讨肠道病毒71型（EV71）所致手足口病临床特点。方法对某院2008年5—8月收治的确诊『手足口病的70例患儿临床资料进行回顾性分析。结果70例手足口病患儿，48例（68．57％）为单纯手足口病，；例（25．71％）有中枢神经系统症状，3例（4．29％）有呼吸系统症状，1例（1．43％）出现循环系统症状；43岁者641（91．43％）；EV71特异性核酸检测，63例（90．00％）阳性，特异性EV71抗体检测70例均为阳性。70例患儿经。疗后，全部好转出院；随访1个月，均无不适，无后遗症发生。结论EV71所致手足口病临床表现较严重，可致：器官损伤。发病者以学龄前儿童为主，尤以≤3岁年龄组发病率高。

Seventy cases of hand foot mouth disease caused by enterovirus 71

Objective To evaluate the clinical characteristics of han＆foot-mouth disease caused by enterovirus 71 （EV71）. Methods Clinical data of 70 cases of hand-foot-mouth disease admitted in a hospital from May, 2008 to August, 2008 were analysed. Results Among 70 cases, 48（68. 57%） were simple hand-foot-mouth disease,18 cases（25.71 %） had central nervous system symptoms, 3 （4. 29 %） had respiratory system symptoms, 1 （1.43 %） had circulatory system symptoms; 64 cases（91.43%） were≤ 43 years old ;63 cases （90. 00%） were positive in specific nucleic acid detection of EV71, 70 cases were all positive in specific antibody detection of EV71. All patients were improved and discharged after treatment. One month follow-up showed that no patient had discomfort and sequelae. Conclusion Clinical manifestations of hand-foot-mouth disease caused by EV71 are serious, and can cause multi-organ impairment. The main patients were pre-school children, especially children≤3 years old.