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骨髓间充质干细胞在缺血性心脏病中的作用机制及其应用
引用本文:李林岭. 骨髓间充质干细胞在缺血性心脏病中的作用机制及其应用[J]. 国际病理科学与临床杂志, 2011, 31(2): 181-184. DOI: 10.3969/j.issn.1673-2588.2011.02.019
作者姓名:李林岭
作者单位:川北医学院附属医院心血管内科,四川,南充,637007
摘    要:
缺血性心脏病是一类严重危害人类健康的疾病.在积极开展各种药物和介入治疗的同时,细胞疗法已成为当下心血管领域的一大热点,骨髓间充质干细胞通过移植或骨髓动员至缺血心脏后能有效改善急性心肌梗死患者短期的心功能.本文就骨髓间充质干细胞疗法在缺血性心脏病中的作用机制及其应用的最新研究成果作一综述.

关 键 词:缺血性心脏病  间充质干细胞  旁分泌效应

Mechanisms and application of mesenchymal stem cells in ischemic heart disease
LI Linling. Mechanisms and application of mesenchymal stem cells in ischemic heart disease[J]. Journal of International Pathology and Clinical Medicine, 2011, 31(2): 181-184. DOI: 10.3969/j.issn.1673-2588.2011.02.019
Authors:LI Linling
Affiliation:LI Linling,L Zhan(Department of Cardiovascular Medicine,Affiliated Hospital of North Sichuan Medical College,Nanchong Sichuan 637007,China)
Abstract:
Ischemic heart disease is a great threat to human health.Besides the drugs and interventional therapy,cell therapy has been becoming a hot topic in cardiovascular field.Bone marrow mesenchymal stem cells(MSCs) could improve the short-term cardiac function of patients with acute myocardial infarction when MSCs were transplanted or mobilized into the ischemic myocardium.This review summarized the latest advances in the mechanisms and application of MSCs in ischemic heart disease.
Keywords:ischemic heart disease  mesenchymal stem cells  paracrine effect  
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