In vitro activities of 10 combinations of antifungal agents against the multiresistant pathogen Scopulariopsis brevicaulis |
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Authors: | Cuenca-Estrella Manuel Gomez-Lopez Alicia Buitrago Maria J Mellado Emilia Garcia-Effron Guillermo Rodriguez-Tudela Juan L |
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Affiliation: | Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda (Madrid), Spain. mcuenca-estrella@isciii.es |
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Abstract: | The activities of 10 combinations of antifungal agents against 25 clinical isolates of Scopulariopsis brevicaulis were tested by the checkerboard technique. An average indifferent effect was detected for all combinations. Synergy was observed for some isolates and combinations, particularly with posaconazole-terbinafine (68% of strains), amphotericin B-caspofungin (60%), and posaconazole-caspofungin (48%). |
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