| JM细胞培养上清对人B淋巴细胞和小鼠脾细胞增殖的免疫调节作用 |
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| 引用本文： | 许辉,金伯泉.JM细胞培养上清对人B淋巴细胞和小鼠脾细胞增殖的免疫调节作用[J].中国免疫学杂志,1992,8(1):31-34. |
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| 作者姓名： | 许辉 金伯泉 |
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| 作者单位： | 第四军医大学免疫学教研室 西安710032 |
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| 摘 要： | JM 是来自人胸腺不成熟 T 细胞的急性淋巴细胞白血病细胞系.本文以 SAC 刺激的人外周血纯化 B 淋巴细胞和小鼠脾细胞增殖为模型,观察了 JM 细胞培养上清(SPN_(JM))对人 B 淋巴细胞和小鼠脾细胞增殖的免疫调节作用.发现具有 T 细胞抑制活性的 SPN_(JM)对人和小鼠 B 淋巴细胞的增殖具有促进作用。在无 SAC 诱导时,SPN_(JM)与 HrIL—2协同对 B 细胞仍有促增殖作用.本实验还发现,高浓度时对 T 细胞具有抑制作用的 SPN_(JM),在低浓度时(1:640)对 T 细胞增殖亦具有促进作用.
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| 关 键 词： | 因子 淋巴细胞 免疫调节 JM 白血病 |
Immunoregulation effect of supernatants from JM cell culture(SPN_(JM))on proliferation of human B lymphocytes and mouse spleen cells |
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| XU Hui,et al..Immunoregulation effect of supernatants from JM cell culture(SPN_(JM))on proliferation of human B lymphocytes and mouse spleen cells[J].Chinese Journal of Immunology,1992,8(1):31-34. |
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| Authors: | XU Hui |
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| Institution: | XU Hui,et al.Department of Immunology,fourth Military Medical University,Xi'an 710032 |
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| Abstract: | JM is a acute lymphocytic leukemia cell line derived from immature T lymphocytes in human thymus.We bserved the immunoregulation effect of supernatants from JM cell culture(SPN_(JM))onproliferation of human B ymphocytes and mouse spleen cells by using purified human B lymphocytesand mouse spleen cells stimulated with AC.It is showed that SPN_(JM),which suppresses T lymphocyteproliferation,enhance the proliferation response of uman B cell and mouse spleen cells stimulatedwith SAC.Without inducement of SAC,SPN_(JM) with HrIL-2 still nhances B lympohocyteproliferation.Additionally,SPN_(JM) is able to up regulate T cell proliferation response at lowconcentration(1:640)although it suppresses T cell proliferation at high concentration. |
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| Keywords: | Cytokine Lymphocyte Immunoregulation Acute lymphocytic leukemia |
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