补充硒对人体镉代谢的影响

给云南锡矿地区冶炼厂工人每日补充硒150μg,连续3周,其血硒含量和GSH-Px活性明显增高,血清LP含量则无变化;镉的排泄量亦增加,并可使红细胞镉含量降低,从而减少镉的蓄积。为矿区肿瘤预防提供了理论依据。

Influence of Selenium Supplement on Cadmium Metabolism in Human

38 subjects were randomly divided into 2 groups of 19 each. Group 1 consumed a selenium supplement (150 micrograms/d X 21) and Group 2 received only placebo(glucose). After supplementation, blood Se levels and plasma GSH-Px activities in Group 1 increased from 76 to 100 ng/ml (P less than 0.05) and 0.082 to 0.122 e.u./ml (P less than 0.01) respectively. All measured Se, GSH-Px values in Group 2, and high concentrations of lipid peroxides (greater than 4 nmol/ml as malonaldehyde) in both groups remained approximately the same. Se supplementation resulted in a marked decrease of RBC cadmium (Cd) from 32.3 to 25.4 micrograms/g Hb (P less than 0.001). Urinary and fecal Cd in 5 subjects of each group were analyzed every 4 days, and the results demonstrated that Cd was mainly excreted in feces after Se supplementation. One week after discontinuing of Se treatment, Cd content in urine and feces decreased to control levels. Theoretical evidence for chemoprevention of lung cancer with Se in this area was thus provided.