年轻中心型肥胖者QT离散度及颈动脉粥样硬化关系的研究

目的探讨年轻单纯性中心型肥胖者QT离散度(QTd、QTcd)及颈动脉粥样硬化的关系。方法选择18~35岁单纯性中心型肥胖38例及年龄与肥胖者相匹配的正常体重34例,分别测量体重指数(BMI)、腰臀比(WHR)、QTd、QTcd值;超声检测颈动脉内中膜厚度(IMT)及有否斑块。结果肥胖者的血压增高、BMI、WHR、QTd、QTcd增大,与正常体重者比较差异有统计学意义(P<0.05);QT离散度>50 ms者发生IMT异常的危险度高于QT离散度<50 ms者(OR=7.0,P<0.05)。结论年轻人单纯性中心型肥胖者QT离散度大于正常参考值,颈动脉内中膜异常;QT离散度>50 ms时其发生动脉粥样硬化的危险性增加;QT离散度可作为预测心血管病变的一项参考指标。

Study on the relationship between the central obesity youth and the electrocardiographic QT dispersion plus carotid atherosclerosis

Objective To explore the relationship between the simple central obesity youth and the electrocardiographic QT dispersion plus carotid atherosclerosis.Methods Thirty eight patients with simple central obesity(obesity group) whose ages were from 18-35 years,and 34 normal weight healthy control subjects(control group) whose ages matched the obesity group's were chosen.To measure the body mass index(BMI),blood pressure,waist-hip ratio(WHR),QTd and QTcd.Ultrasound was used to examine the intima-media thickness(IMT) of carotid and find out whether there are plaques on the patients' carotid artery or not.Results The systolic blood pressure and diastolic blood pressure of central obesity patients were higher than normal value,in the obesity group,there was BP and the BMIs,WHRs,QTds,QTcds were higher than coutrol group,significant difference(P<0.05);Thirty dispersions were over 50 millisecond in the obesity group(78.95%).Seven patients' IMTs were found unsmooth and there were plaques on their carotid wall arterialunder the examination of ultrasound(18.42%),and the rate of those two ratios was 31.36.When QT dispersion is over 50 millisecond,the risk estimate of IMT abnormity is higher than QT dispersion that was less than 50 millisecond(OR=7.0,P<0.05).Conclusion Of the youth who are simple central obesity and age from 18-35 years,QT dispersions are over the normal reference value and intima-media thickness are abnormal.They would get more chances to get carotid atherosclerosis when the QT dispersion is over 50 millisecond;its prompted QT dispersion is a reference index which could forecast the vessel disease;the one whose QT dispersion>50 millisecond should be examined by the ultrasound and be followed up,in order to detect carotie atherosclerosis early.