首页 | 本学科首页   官方微博 | 高级检索  
检索        


Early infections of Toxoplasma gondii and the later development of schizophrenia
Authors:Mortensen Preben Bo  Nørgaard-Pedersen Bent  Waltoft Berit L  Sørensen Tina L  Hougaard David  Yolken Robert H
Institution:The National Centre for Register-based Research, University of Aarhus, Taasingegade 1, 8000 Aarhus C, Denmark. pbm@ncrr.dk
Abstract:Early exposure to several infectious agents has been associated with the later development of schizophrenia. Two recent studies assessed in utero or early postnatal exposure to Toxoplasma gondii. In one study of 63 individuals, who developed schizophrenia spectrum disorders, maternal sera obtained during pregnancy showed an increased risk (OR 2.61) of having IgG antibodies to T. gondii. In the other study of 71 individuals who developed schizophrenia, sera obtained shortly after birth also showed an increased risk (OR 1.79) of having IgG antibodies to T. gondii. Causal linking mechanisms are at present speculative but include possible direct effects of maternal IgG on the developing central nervous system (CNS) of the offspring. Additional studies are underway.
Keywords:birth cohort  nested case-control study  biobank
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号