计算机辅助组织工程在组织支架仿生建模和设计中的应用

计算机辅助组织工程(CATE)可以帮助进行复杂组织支架的建模,设计和制造,使很多用于改善替代材料力学及生物学性能的新方法得以实施。CATE通过获取组织的生物学、生物力学及生物化学信息,进行界面的设计、模拟和组织的制作。本文将讲述CATE在骨组织工程支架仿生设计中的应用:介绍运用CATE进行仿生建模,解剖结构重建,组织支架设计,定量CT分析,有限元分析和支架的自由挤压沉积制作。

Computer aided tissue engineering: application to biomimetic modeling and design of tissue scaffold

Computer-Aided Tissue Engineering (CATE) enables many novel approaches in modeling, design, and fabrication of complex tissue substitutes with enhanced functionality and improved cell-matrix interactions. Central to CATE is its bio-tissue informatics model that represents tissue biological, biomechanical, and biochemical information that serves as a central repository to interface design, simulation and tissue fabrication. This paper presents a study of applying CATE approach for the biomimetic design of bone tissue scaffold. A general CATE-based process for biomimetic modeling, anatomic reconstruction, CAD model based tissue scaffold design, quantitative computed tomography characterization, finite element analysis and freeform extruding deposition for fabrication of scaffold is presented.