糖尿病大鼠肠道Cajal间质细胞结构变化的研究

目的：明确糖尿病时肠道Cajal间质细胞超微结构的变化。方法：对12周四氧嘧淀糖尿病大鼠模型的小肠、结肠组织进行透射电镜观察。结果：实验观察发现糖尿病时Cajal间质细胞与其他细胞间的缝隙连接显著减少、结构破坏、连接松散;线粒体肿胀、空泡样变、溶解;胞质广泛溶解,细胞器减少。结论：糖尿病时肠道Cajal间质细胞的超微结构发生了显著的变化,这些结构的改变与其功能的改变密切相关,Cajal间质细胞超微结构的变化很可能是糖尿病胃肠功能紊乱的病因之一。

Changes of ultrastructure characteritics of Cajal interstitial cell in intestinal tract of diabetic rats

Objective This study is to clarify the changes of the ultrastructure characteristic of Cajal interstitial cell of diabetic rats intestinal tract. Methods Male SD rats were randomly divided into two groups: group A (diabetic), group B (control). 45mg/kg Alloxan was injected into the group A, group B was injected with saline instead, after 12 weeks , the tissues of small intestine,colon were observed through electric telescope. Results The major change of Cajal interstitial cell of diabetic rat were showed as below : the number of the gap junctions between Cajal interstitial cell and neuron cells , between Cajal interstitial cell and myocyte , and between themselves were decreased significantly, and the structure of those gap junctions rested were also damaged; mitochondrion was swelling?vacuoles?dissolving ; cytoplasm was dissolving, vacuoles were formed ; the organelle were decreased .Conclusions The ultrastructure of Cajal interstitial cell of diabetic had striking changes, these changes are closely related with the changes of their function ,so it is very possible that these changes are one of the mechanisms of diabetic gastrointestinal dysfunction.