Circulating atrial natriuretic polypeptide in essential hypertension |
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| Authors: | M Kohno K Yasunari T Matsuura K Murakawa T Takeda |
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| Affiliation: | 1. Department of Cardiology, Kameda Medical Center, Chiba, Japan;2. University of Groningen, Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands;3. Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan;4. Department of Cardiology, St. Marianna University School of Medicine, Kawasaki, Japan;5. Department of Cardiology, Himeji Cardiovascular Center, Himeji, Japan;6. Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan;7. Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan;8. Cardiovascular Division, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;9. Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan;10. Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio;11. Departments of Epidemiology & Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts;12. Department of Cardiovascular Medicine, Juntendo University, Tokyo, Japan;13. Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan;13. Hospital Universitario de Salamanca;14. Hospital Marqués de Valdecilla de Santander;15. Hospital Clínico San Carlos de Madrid;p. Hospital Clínic de Barcelona;q. Hospital Politénic La Fe de Valencia;r. Hospital Dr. Negrín de Las Palmas de Gran Canaria;s. Hospital Reina Sofía de Córdoba;t. Hospital Dr. Peset de Valencia;u. Hospital del Mar de Barcelona;v. Hospital de Valme de Sevilla;w. Hospital de Alcorcón de Madrid;x. Consorci Sanitari de Terrassa;y. Hospital Universitario Rio Hortega de Valladolid;z. Hospital Reina Sofía de Murcia;11. Hospital Severo Ochoa de Madrid;12. Hospital de la Santa Creu y Sant Pau de Barcelona;13. Hospital Universitari de Bellvitge de Barcelona;14. Hospital Universitario de Burgos;15. Hospital Universitario Central de Asturias de Oviedo;16. Hospital General Universitario de Alicante;17. Hospital General Universitario Gregorio Marañón de Madrid;18. Hospital Universitario de Getafe de Madrid;19. Hospital de Henares de Madrid;110. Hospital Clínico Lozano Blesa de Zaragoza;111. Hospital Sant Pau i Santa Tecla de Tarragona;112. Hospital Universitario de Canarias de Tenerife;113. Althaia Xarxa Assistencial Universitaria de Manresa;114. Hospital Costa del Sol de Marbella de Málaga;115. Hospital Josep Trueta de Girona;1p. Hospital Virgen Macarena de Sevilla;1q. Hospital General Universitario de Albacete;1r. Hospital Juan XXIII de Tarragona;1s. Hospital Universitario Infanta Leonor de Madrid;1t. Hospital Vall d´Hebron de Barcelona;1u. Hospital Francesc de Borja de Gandia;1v. Hospital de Manacor de Mallorca;1w. Hospital la Mancha de Ciudad Real;1x. Hospital Comarcal Valle de los Pedroches de Córdoba;1y. Hospital Universitario de la Paz de Madrid;1z. Hospital Clínico de Valencia;21. Hospital Universitario de Móstoles de Madrid;1. Emergency Department, Hospital Clínic, Institut d''Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain;2. The GREAT network, Rome, Italy;3. Cardiology Department, Hospital Clínico de Valencia, INCLIVA, Valencia, Spain;4. Internal Medicine Department, Hospital d''Olot, Girona, Catalonia, Spain. Laboratori de Reparació i Regeneració Tissular (TR2Lab), Institut de Recerca i Innovació en Ciències de la Vida i de la Salut a la Catalunya Central (IrisCC), Vic, Barcelona, Catalonia, Spain;5. Cardiology Department, University Hospital of Basel, Cardiovascular Research Institute Basel, Basel, Switzerland;6. Emergency Department, Althaia Xarxa Assistencial Universitaria, Manresa, Catalonia, Spain;7. Emergency Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain;8. Emergency Department, Hospital Universitari de Bellvitge, l''Hospitalet de Llobregat, Barcelona, Catalonia, Spain;9. Emergency Department, Short Stay Unit and Hospitalization at Home Unit, Hospital General de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Universidad Miguel Hernández, Alicante, Spain;10. Internal Medicine Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.;11. Emergency Department, Hospital del Mar, Barcelona, Catalonia, Spain.;12. Emergency Department, Hoispital Francesc de Borja, Gandia, Spain;1. Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan;2. Second Department of Internal Medicine, University of Toyama, Toyama, Japan;3. Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center, Osaka, Japan;4. Omics Research Center, National Cerebral and Cardiovascular Center, Osaka, Japan;5. Department of Clinical Chemistry, National Cerebral and Cardiovascular Center, Osaka, Japan;6. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan |
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| Abstract: | To investigate the significance of atrial natriuretic polypeptide (ANP) in essential hypertension, we measured plasma ANP concentrations in 43 subjects with essential hypertension uncomplicated by cardiac or renal failure, in 16 subjects with borderline hypertension, and in 17 normotensive control subjects. Plasma ANP levels were significantly higher in hypertensive subjects compared to borderline hypertensive subjects (p less than 0.05) and normotensive control subjects (p less than 0.05). Hypertensive subjects with left ventricular hypertrophy (LVH) had higher plasma ANP levels than the hypertensive group as a whole (p less than 0.05). A significant positive correlation was observed between mean blood pressure and plasma ANP level in the hypertensive group (n = 43, gamma = 0.77, p less than 0.01). Furthermore, plasma ANP level was decreased significantly after 4 weeks of effective antihypertensive therapy compared with the initial value (p less than 0.05). These results suggest that plasma ANP is frequently elevated in hypertensive subjects with markedly high blood pressure or LVH, and it can be reduced by effective therapy with antihypertensive drugs. |
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