| 核EGFR:潜在放疗增敏靶点研究进展 |
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| 引用本文： | 张婷婷,刘宝财,程光惠.核EGFR:潜在放疗增敏靶点研究进展[J].中华放射肿瘤学杂志,2018,27(1):116-120. |
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| 作者姓名： | 张婷婷 刘宝财 程光惠 |
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| 作者单位： | 130000 长春,吉林大学中日联谊医院放疗科 |
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| 基金项目： | 国家自然科学基金项目(31600679);吉林省科技厅社发处项目(20090458);吉林省卫生计生委项目(2014ZC054);吉林省科技厅自然基金(白求恩专项)项目(20160101079JC);吉林大学横向课题(2015373) |
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| 摘 要： | 细胞核内EGFR在肿瘤发生发展、转移、治疗及预后等方面发挥重要的生物学作用。放疗作为治疗恶性肿瘤的主要手段之一,在治疗恶性肿瘤的同时可引起EGFR转移入核,从而降低放疗敏感性。深入了解核EGFR的生物学特性及其功能对提高放射敏感性有重要的参考价值,笔者从EGFR转运入核、核EGFR特性及其与放射敏感性和临床靶向治疗关系等几个方面做一综述。
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| 关 键 词： | 表皮生长因子受体 放射敏感性 肿瘤/靶向疗法 |
| 收稿时间： | 2017-06-15 |
Nuclear EGFR:a potential target for radiosensitizer |
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| Zhang Tingting,Liu Baocai,Cheng Guanghui.Nuclear EGFR:a potential target for radiosensitizer[J].Chinese Journal of Radiation Oncology,2018,27(1):116-120. |
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| Authors: | Zhang Tingting Liu Baocai Cheng Guanghui |
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| Institution: | Department of Radiation Oncology,China-Japan Union Hospital of Jilin university,Changchun 130000,China |
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| Abstract: | Nuclear epithelial growth factor receptor (EGFR) plays an important role in the development, metastasis, treatment, and prognosis of cancer. Radiotherapy, one of the main therapies for malignant tumor, causes EGFR transfer into the nucleus along with tumor therapy, thereby reducing radiosensitivity. Insight into the biological characteristics and functions of nuclear EGFR has an important reference value for improving radiosensitivity. Therefore, this article elaborates on EGFR transport into the nucleus, the features of nuclear EGFR, and its relationship with radiosensitivity and clinical targeted therapy. |
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| Keywords: | Epidermal growth factor receptor Radiosensitivity Neoplasms/targeted therapy |
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