蛋白质类纳米载体材料的研究进展

纳米技术为制药领域、特别是药物输送领域提供了新的策略，其中，蛋白质作为药物分子的纳米载体备受关注。蛋白质纳米载药系统是以动物、植物或重组蛋白质为载体，与药物共同组成的纳米载药体系，具有良好的生物相容性、生物降解性、低抗原性、较高的稳定性及载药性等优点，在临床治疗尤其是肿瘤的靶向治疗等领域具有重要意义。本文从动物来源的蛋白质、植物来源的蛋白质以及重组蛋白质的理化性质、功能特性介绍入手，总结了蛋白质类纳米载体在药物递送载体中的应用现状，并探讨了蛋白质纳米载体的发展方向。

Advances in the research of protein nanocarrier materials

Nanotechnology has brought new strategies in the area of pharmaceutical sciences, especially in the drug delivery system. Among them, the application of protein as drug carriers has drawn extensive attention. A wide variety of proteins that have been used fordrug delivery system including the common animal- and plant-basedproteins, as well as the recombinant protein nanoparticles, which possess many advantages such as biocompatibility, biodegradability, low antigenicity, higher stability and drug loading property. This system is of great significance in the fields of clinical treatment, especially targeted therapy of tumors. In this paper, the fabrication of nanoparticles from animal, botanical, and recombinant proteins are described. And then, trend of development in protein-based nanocarriers is also prospected.