三维细胞模型在肿瘤研究中的应用

三维细胞模型借助特殊材料或载体在体外培养不同种类的细胞，使细胞在三维环境中生长、迁移和分化。三维细胞模型为细胞提供接近体内生存的体外环境，使细胞的基因表达、信号传递更具生理学相关性。本文从三维细胞模型的概念与分类入手，综述了近几年三维细胞模型在肿瘤微环境、肿瘤转移与抗肿瘤药物研发的应用与进展。基于三维细胞模型目前存在的不足，对其在肿瘤治疗中的应用提出了设想与展望。

Application of three-dimensional cell model in tumor research

The three-dimensional cell model cultures different types of cells in vitro. By means of special materials or carriers, the cells can grow, migrate and differentiate in a three-dimensional environment. The three-dimensional cell model provides the cells with an in vitro environment that is close to in vivo, making the gene expression and signal exchange of the cells more physiologically relevant. This paper starts with the concept and classification of three-dimensional cell model, then summarizes the applications and progresses of three-dimensional cell model in tumor micro-environment, cancer metastasis and anti-tumor drug development in recent years. Based on the current shortcomings of the three-dimensional cell model, this paper presents the assumptions and prospects for the application of three-dimensional cell model in tumor therapy.