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| 引用本文： | ����,���ϼ,��,�¶���,��ΰ,���,���. ���̴�-���Ҷ������ε�����ù��B֬�ʸ������Ʊ���ҩ��ѧ[J]. 中国药学杂志, 2018, 53(5): 371-374. DOI: 10.11669/cpj.2018.05.011 |
| 作者姓名： | ���� ���ϼ �� �¶��� ��ΰ ��� ��� |
| 作者单位： | 1. ?????е????,???? 050051; 2. ?????????????????(????)??????,???? 050035; 3. ?????????????????????????,???? 050035; 4. ?????е?????,???? 050024 |
| 摘 要： | |
| 关 键 词： | ????ù??B ?????-??????? ???????? ???? |
Preparation of Cholesterol-PEG-Modified Amphotericin B Liposomes and the Pharmacokinetics in Rats |
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| XIU Xian,FENG Cai-xia,BAI Jing,CHEN Dong-jian,ZHAO Wei,LI Chen-xiao,ZANG Lan. Preparation of Cholesterol-PEG-Modified Amphotericin B Liposomes and the Pharmacokinetics in Rats[J]. Chinese Pharmaceutical Journal, 2018, 53(5): 371-374. DOI: 10.11669/cpj.2018.05.011 | |
| Authors: | XIU Xian FENG Cai-xia BAI Jing CHEN Dong-jian ZHAO Wei LI Chen-xiao ZANG Lan |
| Affiliation: | 1. The Second Hospital of Shijiazhuang, Shijiazhuang 050051, China; 2. CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., Shijiazhuang 050035, China; 3. State Key Lab of Novel Pharmaceutical Preparations and Excipients,Shijiazhuang 050035, China; 4. The Fifth Hospital of Shijiazhuang, Shijiazhuang 050024,China |
| Abstract: | ??OBJECTIVE To prepare cholesterol-PEG-modified amphotericin B liposomes and amphotericin B liposomes, and evaluate their encapsulation efficiency and pharmacokinetics. METHODS It was employed to prepare both kinds of liposomes with the film-evaporation, the dynamic light scattering techniques and Ultrafree-CL were used to determine the mean diameter and the encapsulation efficiency, respectively. Pharmacokinetics was evaluated in Wista rats. RESULTS Mean diameter of the liposomes was (115??20) nm,and the encapsulation efficiency was over 99.9%. Moreover, the pharmacokinetic study in rats indicated that cholesterol-PEG-modified liposomes could significantly increase the ??max and AUC. CONCLUSION Amphotericin B liposomes prepared by film-evaporation method have high encapsulation efficiency, and cholesterol-PEG modification can prolong the circulation time of amphotericin B in vivo. |
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