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Meta-Analysis on Antibiotics Usage in Children with Upper Respiratory Tract Infection in China

??OBJECTIVE To understand the condition of antibiotics usage in children with upper respiratory tract infection in China, so as to evaluate the effectiveness of rational drug use policy since the new health care reform promulgated by the state.METHODS Publications were extracted from China National Knowledge Infrastructure(CNKI),Chinese Science and Technology Journal Database(VIP),Wanfang Databases, PubMed, Ebsco, Web of Science and Embase, then Meta-analysis was carried out on them, at the same time, do comparative study on times, regions and categories. RESULTS Thirty three papers were included for Meta-analysis with a total sample of 54 189.Meta-analysis showed that the combined rate of antibiotics usage in children with upper respiratory tract infection in China was 89.2%(95%CI=82.2%-96.2%.Before 2009, the antibiotics use rate was 92.2%,and it turned to be 87.6% after 2009. The antibiotics use rate of eastern,central and western children was 88.3%,88.4% and 93.3%. Tertiary hospitals was 85.2%,secondary hospitals was 92.2% and primary medical institutions(including first level hospitals,community health service centers and township health centers) was 90.2%.CONCLUSION Children's antibiotic use rate of upper upper respiratory tract infection is high in China and the rate is different at different times,regions and institutions. After the health care reform policy was enacted,the use rate of antibiotics fell,this may be related to the implementation of the policy.