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Evaluation on Interventions for Chemotherapy Induced Thrombocytopenia

??OBJECTIVE To compare the efficacy of different interventions on chemotherapy induced thrombocytopenia (CIT) in solid tumors. METHODS Patients, registered at Fudan University Shanghai Cancer Center, who developed CIT (defined as platelet count < 100??10⁹??L^-1) during May 2014 and April 2015 were retrospectively enrolled. The patients were divided into recombinant human interleukin 11 (rhIL-11) group, recombinant human thrombopoietin (rhTPO) group, combination group and non-treatment group. Complete remission rate (CR), recovery time and recurrence rate were calculated to compare the efficacy of interventions. P<0.05 was considered as statistical significant. RESULTS A total of 281 eligible patients were enrolled. No significant difference were found on recovery rate of different interventions in each grade of CIT (P>0.05). Recovery time were similar between interventions, most group had a median recovery time of 6 or 7 d. In grade ?? CIT, the recovery time of combination group is shorter than the other intervention groups (5.5 d in combination group vs 7 d in rhTPO group and rhIL-11 group), but there was no significant difference (P=0.609, 0.605). In grade ?? CIT, the recurrence rate was significantly higher in rhTPO group and rhIL-11 group than untreated group (35%, 38% vs 0%, P=0.008, P=0.006). In grade ?? CIT, the recurrence rate of rhTPO group was significantly higher than that of rhIL-11 group (55% vs 21%, P=0.017). CONCLUSION The result of the current study suggests that thrombopoietic agents are not recommended for patients with ??-?? CIT. For ??-?? CIT, no significant differences are found in the efficacy between different interventions, thus rhIL-11 is recommended in consideration of cost.