Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls,whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK-MB accuracy |
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| Institution: | 1. Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece;2. Department of Cardiology, 424 General Military Hospital, Thessaloniki, Greece;3. Department of Cardiology, Skaraborg Hospital, Skovde, Sweden;4. Department of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;5. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;6. Department of Hygiene and Epidemiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;7. Department of Pharmacology, 424 General Military Hospital, Thessaloniki, Greece;1. Unit of Nutritional Epidemiology, The National Institute for Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden;2. Department of Surgical Sciences, Section of Orthopedics, Uppsala University, Akademiska sjukhuset, 751 85 Uppsala, Sweden;3. Department of Public Health, Environmental Medicine, University of Southern Denmark, Winsløws Vej 17, Odense, Denmark;4. Department of Molecular Medicine and Surgery, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden;1. Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China;2. Tianjin University of Traditional Chinese Medicine, Tianjin, China;3. Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China;1. Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, PR China;2. Department of Human Anatomy, Southwest Medical University, Luzhou, Sichuan, PR China;3. Center of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi, PR China;4. Department of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, PR China;5. Department of Epidemiology and Health Statistics, Guilin Medical University, Guilin, Guangxi, China;1. National Children''s Research Centre, Our Lady''s Children''s Hospital, Crumlin, Gate 5, Dublin 12, Dublin, Ireland;2. Conway Institute of Biomolecular and Biomedical Research, School of Medicine & Medical Science, University College Dublin, Belfield, Dublin, 4, Dublin, Ireland |
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| Abstract: | BackgroundSeveral myokines are produced by cardiac muscle. We investigated changes in myokine levels at the time of acute myocardial infarction (MI) and following reperfusion in relation to controls.MethodsPatients with MI (MI Group, n = 31) treated with percutaneous coronary intervention (PCI) were compared to patients with stable coronary artery disease (CAD) subjected to scheduled PCI (CAD Group, n = 40) and controls with symptoms mimicking CAD without stenosis in angiography (Control Group, n = 43). The number and degree of stenosis were recorded. Irisin, follistatin, follistatin-like 3, activin A and B, ALT, AST, CK and CK-MB were measured at baseline and 6 or 24 h after the intervention.ResultsMI and CAD patients had lower irisin than controls (p < 0.001). MI patients had higher follistatin, activin A, CK, CK-MB and AST than CAD patients and controls (all p ≤ 0.001). None of the myokines changed following reperfusion. Circulating irisin was associated with the degree of stenosis in all patients (p = 0.05). Irisin was not inferior to CK-MB in predicting MI while folistatin and activin A could discriminate MI from CAD patients with similar to CK-MB accuracy. None of these myokines was altered following PCI in contrast to CK-MB.ConclusionsIrisin levels are lower in MI and CAD implying that their production may depend on myocadial blood supply. Follistatin and activin A are higher in MI than in CAD suggesting increased release due to myocardial necrosis. They can predict MI with accuracy similar to CK-MB and their role in the diagnosis of MI remains to be confirmed by prospective large clinical studies. |
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