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| 催经止孕药Ru-486的临床药代动力学 | |
| 引用本文： | 石永恩,叶智厚,贺昌海,张国庆,朱月华,白秀梅,郑树衡,虞培萍. 催经止孕药Ru-486的临床药代动力学[J]. 生殖与避孕, 1987, 0(3) |
| 作者姓名： | 石永恩 叶智厚 贺昌海 张国庆 朱月华 白秀梅 郑树衡 虞培萍 |
| 作者单位： | 上海计划生育科学研究所(石永恩，叶智厚，贺昌海，张国庆，朱月华，白秀梅，郑树衡)，上海计划生育科学研究所(虞培萍) |
| 摘 要： | 应用高效液相色谱法(HPLC)研究了抗孕激素药,Ru-486的临床药代动力学。六名志愿受试者,一次口服Ru-486 50毫克后测得该药的药代动力学各项参数,血药半寿期t 1/2 33.0小时,一级消除速率常数Kel 0.021 hr~(-1),血药表观容积Vd 120.1 Liter,体内血药总廓清率Cl2.5 Liter/hr,药-时曲线下面积Auc 19825.1 ng/ml/hr。实验表明,服药后一小时血药浓度迅即达高峰,随后转入消除期,血浆药物浓度在消除相的头4～8小时消除较快,而后逐渐减慢,持续24小时,到48小时血药浓度已较低(0.15±0.07μg/ml)。 |
CLINICAL PHARMACOKINETICS STUDY OF Ru-486 |
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| Shi Yong-en Ye Zhi-hou He Chang-hai Zhang Guo-qin Zhu Yue-hua Bai Xiu-mei Zheng Shu-heng Yu Pei-ping. CLINICAL PHARMACOKINETICS STUDY OF Ru-486[J]. Reproduction and Contraception, 1987, 0(3) | |
| Authors: | Shi Yong-en Ye Zhi-hou He Chang-hai Zhang Guo-qin Zhu Yue-hua Bai Xiu-mei Zheng Shu-heng Yu Pei-ping |
| Affiliation: | Shanghai Institute of Planned Parenthood Research |
| Abstract: | The study on the clinical pharmacokineties of antiprogestin was done by the HPLC method. The main parameters obtained after single administration of Ru-486 50mg in six women were: t 1/2 33.0hr., Kel 0.021hr., Vd 120.1L, Cl 2.52/hr, AUC 19825.1ng/ml/hr. The results indicate that the drug was rapidly absorbed and the plasma levels of Ru-486 attained a peak value within 7 hours after the pill was given orally, and then entered in to elimination phase. The drug plasma levels declined very rapidly at the first 4～8hrs. However, the elimination rate was slow and the plasma levels remained in a steady state until 24 hrs after administration. The plasma level was very low (0.15±0.07μg/ml) after 48 hrs. |
| Keywords: | Clinical phamacokinetics Ru 486 |
| 本文献已被 CNKI 等数据库收录！ | |