| 用气相色谱研究抗氧化剂对膜脂肪酸的保护作用 |
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| 引用本文： | 卢基贵,王伟,陈文为. 用气相色谱研究抗氧化剂对膜脂肪酸的保护作用[J]. 药学学报, 1991, 26(6): 406-410 |
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| 作者姓名： | 卢基贵 王伟 陈文为 |
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| 作者单位： | 北京中医学院中心实验室，北京中医学院中心实验室，北京中医学院中心实验室 北京 100029，北京 100029，北京 100029 |
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| 基金项目： | 国家自然科学基金(3880903) |
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| 摘 要： | 本文应用气相色谱技术直接测定三种生物膜(人红细胞膜,人血小板膜和鼠肝线粒体膜)多不饱和脂肪酸的含量变化,检测脂质过氧化程度。实验证实几种多羟酚类化合物(儿茶精,阿魏酸钠和没食子酸及其衍生物)不同程度地抑制(OH)诱导的脂质过氧化反应,并呈量效和构效关系。这类抗氧化剂对保护生物膜的结构与功能是有益的。
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| 关 键 词： | 气相色谱 抗氧化剂 生物膜 脂质过氧化 |
| 收稿时间： | 1990-05-28 |
PROTECTION OF BIOMEMBRANE FATTY ACIDS BY ANTIOXIDANTS STUDIED WITH GAS C(?)ROMATOGRAPHY |
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| JG Lu,W Wang and WW Chen. PROTECTION OF BIOMEMBRANE FATTY ACIDS BY ANTIOXIDANTS STUDIED WITH GAS C(?)ROMATOGRAPHY[J]. Acta pharmaceutica Sinica, 1991, 26(6): 406-410 |
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| Authors: | JG Lu W Wang WW Chen |
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| Affiliation: | Central Laboratory, Beijing College of Traditional Chinese Medicine. |
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| Abstract: | A gas chromatography method for the determination of degree of lipid peroxidation of polyunsaturated fatty acids (PUFA) in 3 kinds of biomembrane (human red blood cell, human platelet membrane and mitochondrial membrane of rat liver) was established. The method was used to study the inhibiting effect of several antioxidants on OH. radical induced lipid peroxidation reaction in biomembrane. The results showed that several compounds with phenolic hydroxyl groups (catechuicine, sodium ferulate, gallic acid and its derivatives) have significant protective effect on PUFA of the 3 kinds of biomembrane. |
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| Keywords: | Gas chromatography Antioxidants Biomembrane Lipid peroxidation |
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