| 秋水仙素对大鼠基底前脑Nestin阳性神经元的影响 |
| |
| 引用本文： | 周立兵,阮奕文,姚志彬. 秋水仙素对大鼠基底前脑Nestin阳性神经元的影响[J]. 解剖科学进展, 2003, 9(2): 105-108 |
| |
| 作者姓名： | 周立兵 阮奕文 姚志彬 |
| |
| 作者单位： | 中山大学中山医学院解剖学教研室,广东,广州,510080;中山大学中山医学院解剖学教研室,广东,广州,510080;中山大学中山医学院解剖学教研室,广东,广州,510080 |
| |
| 基金项目： | 国家自然科学基金资助项目 (No 19670 2 44 ) |
| |
| 摘 要： | 目的 探讨侧脑室注射秋水仙素后基底前脑巢蛋白 (Nestin)阳性神经元的表达情况。方法 4 8只成年SD大鼠侧脑室注射 1%秋水仙素或生理盐水 10 μl,分别于术后 12h、2 4h、3d、5d、7d和 14d处死动物。用免疫组织化学方法观察基底前脑Nestin阳性神经元的表达情况。结果 秋水仙素注射后的 2 4h基底前脑的Nestin阳性神经元急骤减少到最低 ,然后逐渐恢复 ,至术后第 14天基本恢复正常。结论 秋水仙素可导致基底前脑的Nestin阳性神经元一过性减少
|
| 关 键 词： | 巢蛋白 基底前脑 秋水仙素 大鼠 免疫组织化学 |
| 文章编号： | 1006-2947(2003)02-0105-04 |
| 修稿时间： | 2003-03-20 |
The Effect of Colchicine on the Nestin-IR Neurons in the Rat Basal Forebrain |
| |
| ZHOU Li bing,RUAN Yi wen,YAO Zhi bin. The Effect of Colchicine on the Nestin-IR Neurons in the Rat Basal Forebrain[J]. Progress of Anatomical Sciences, 2003, 9(2): 105-108 |
| |
| Authors: | ZHOU Li bing RUAN Yi wen YAO Zhi bin |
| |
| Abstract: | Objective To observe the expression of Nestin-IR neurons after infusing colchicine into the lateral ventricle. Method 48 SD rats were infused with 10μl 1% colchicine or normal saline into the lateral ventricle and sacrificed at 12h, 24h, 3d, 5d, 7d and 14d after infusion. The expression of nestin was observed by means of immunohistochemistry. Results 24h after infusion,the number of nestin immoureactive (Nestin IR) neurons reduced to the minimum rapidly then recovered gradually. At the 14d after infusion, the number of Nestin IR neurons completely recovered. Conclusion Colchicine can result in the reduction of the number of Nestin-IR neurons in the rat basal forebrain transiently. [YM5BZ?=105,S] |
| |
| Keywords: | nestin basal forebrain colchicine rat immuohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
