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| 环丙沙星中间体,2,4—二氯—5—氟苯甲酰氯的合成 | |
| 引用本文： | 温新民 陈美荣. 环丙沙星中间体,2,4—二氯—5—氟苯甲酰氯的合成[J]. 济宁医学院学报, 2000, 23(2): 21-22 |
| 作者姓名： | 温新民 陈美荣 |
| 作者单位： | [1]济宁医学院化学教研室 [2]济宁医学院第二教学医院 |
| 摘 要： | 目的合成环丙沙星中间体２，４－二氯－５－氟苯甲酰氯。方法 以１，３－二氯－４－氟苯为原料，经取代，氧化，经三步反应制得。结果 反应条件温和，方法简单，总收率６９％。结论 适用于工业化生产。 |
| 关 键 词： | 氟苯甲酰氯 合成 药物中间体 环丙沙星 |
SYNTHESIS OF 2.4-DICHLORO-5-FLUOROBENZOYL CHLORIEDAS INTERMEDIATE OF CIPROFLXACIN |
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| Wen Xinmin,Chen Meirong,Wang Yan,et al. SYNTHESIS OF 2.4-DICHLORO-5-FLUOROBENZOYL CHLORIEDAS INTERMEDIATE OF CIPROFLXACIN[J]. Jounal of Jinning Medical College, 2000, 23(2): 21-22 | |
| Authors: | Wen Xinmin Chen Meirong Wang Yan et al |
| Abstract: | Objective Synthesis of 2.4-dichloro-5-fluorobenzoyl as the intermediate of Ciproflxacin.Methods 1.3-dichloro-4-fluorobenzene as ran materical,reactions of substitution,oxidation,and acvlation were described.Results The reactions of all steps were carried out in moderate conditions to afford an overall yield of 69%.Conclusion This method was suitable for industrial preparation. |
| Keywords: | 2.4-dichloro-5-fluorobenzoyl chloridc sythcsis intcrmcdiatc for pharmaceuticals. |
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