初诊2型糖尿病治疗后血清ghrelin水平与胰岛β细胞功能的关系

目的研究初诊2型糖尿病患者治疗后血清ghrelin与PG、Ins水平的关系。方法同步测定34例初诊2型糖尿病患者治疗前（DM0）、治疗达标后2周（DM1）及6个月（DM2）静脉糖耐量试验（IVGTT）时血清ghrelin、Ins、PG水平。结果（1）DM1、DM2比DM0胰岛素第一时相分泌、胰岛素曲线下面积均明显增加（P〈0.05）;（2）DM0多点血清ghrelin及ghrelin曲线下面积明显低于DM2（P〈0.05）;（3）DM2空腹血清ghrelin水平与HOMA-β（r=0.446,P〈0.05）呈正相关;与FPG（r=-0.274,P〈0.05）、FIns（r=-0.35,P〈0.05）、BMI（r=-0.276,P〈0.05）呈负相关。结论Ghrelin可能参与了2型糖尿病的发生和发展。

The relationship between the serum ghrelin level and β-cell function after treatment of patients with newly diagnosed type 2 diabetes mellitus

Objective To investigate the relationship between the serum ghrelin level and β-cell function after treatment of patients with newly diagnosed type 2 diabetes mellitus. Methods 34 patients with newly diagnosed type 2 diabetes mellitus were divided into three groups of pre-treatment （DM0）, two weeks after treatment （DM1） and six months after treatment （DM2）. Intravenous glucose tolerance tests （IVGTT） were performed and blood glucose, HbA1C, ghrelin, insulin were measured during the study. Insulin sensitivity was assessed by homeostasis model assessment （HOMA）. Results （1）Compared with DM0 group, beta-cell function and the mean AUC Of insulin were dramatically improved in groups of DM1 and DM2 （all P〈0. 05）. （2） Compared with DM1 and DM2 ,ghrelin levels and the mean AUC of ghrelin in DM0 groups were lower（all P〈0. 05）. （3） Only positive correlation between ghrelin and HOMA-β （r= 0. 446, P〈0. 05）, and negative correlations of ghrelin with glucose（r=-0. 274, P〈0.05）, insulin （r=-0. 35 ,P〈0.05） and BMI（r=-0. 276, P〈0.05） were found after six months of treatment. Conclusions Ghrelin might play an important role in the pathogenesis and progress of type 2 diabetes mellitus.