| 有机磷酸酯类化合物对GABA受体影响的体外研究 |
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| 引用本文： | 彭俊华,曹波,高宁,张峰,齐心亮.有机磷酸酯类化合物对GABA受体影响的体外研究[J].中国公共卫生,2000,16(7):599-600. |
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| 作者姓名： | 彭俊华 曹波 高宁 张峰 齐心亮 |
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| 作者单位： | 1. 兰州军区总医院检验科,兰州,730050
2. 第三军医大学预防医学系环境卫生教研室 |
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| 摘 要： | 探索有机磷酸酯类化合物对大鼠γ－氨基丁酸受体的体外影响，为有机磷酸酯类化合物急性中毒的体内研究提供理论依据。用大鼠脑神经末梢微囊ＧＡＢＡ受体为模型，观察二嗪农、梭曼、益棉磷、乙硫磷、杀螟松、两氟磷等有机磷酸酯类化合物对大鼠ＧＡＢＡ受体的体外反应变化。结果观察到１０ｍｍｏｌ／Ｌ益棉磷、杀螟松、丙氟磷或５ｍｍｏｌ／Ｌ二嗪农、松曼均明显降低大鼠ＧＡＢＡ受体与＾３Ｈ－ＧＡＢＡ的结合率（Ｐ〈０．０１），０．
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| 关 键 词： | 有机磷酸酯类化合物 GABA受体 体外研究 中毒 |
| 修稿时间： | 1999年3月29日 |
Studies on Effects of Organophosphates on GABA Receptors of the Rat Brain in Vitro |
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| Peng Jun-hua.Studies on Effects of Organophosphates on GABA Receptors of the Rat Brain in Vitro[J].Chinese Journal of Public Health,2000,16(7):599-600. |
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| Authors: | Peng Jun-hua |
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| Institution: | lanzhou 730050 |
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| Abstract: | To study the mechanism of GABA receptor of organophosphates(OP)in vitro in order to give the evidencesof studying Op in vivo.Experiment use the model of rat's microsac to observe the change of 3H GABA bining to GABA receptor with diazino,soman,DFP, fenitrothion,azinphos ethyl,ethion acting in vitro.The 3H GABA binding of rat's microsac was significant decreased when 10mmol/L diisopropylfluorophosphate(DFP),fenitrothion,azinphos ethyl or 5mmol/L diazinon,soman were acted on the rat's microsac in virto(P<0\^01).0\^1mmol/L soman or 0\^5mmol/L diaznon were acted on the rat's microsac in vitro,the 3H GABA binding were still significant decreased (P<0 05).The binding of GABA receptor was decreased when organophosphates were acted on the rat's microsac in vitro. |
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| Keywords: | Organophosphates GABA Receptor |
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