| 肝癌荷瘤大鼠立体定向放射治疗的实验研究 |
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| 引用本文： | 丁田贵,尹立杰,彭兆祥.肝癌荷瘤大鼠立体定向放射治疗的实验研究[J].实用肿瘤学杂志,2003,17(2):88-89. |
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| 作者姓名： | 丁田贵 尹立杰 彭兆祥 |
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| 作者单位： | 大连市中心医院伽玛刀治疗中心,大连,116033 |
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| 摘 要： | 目的探讨立体定向放射治疗对肝癌的治疗作用.方法通过CBRH-3肝癌细胞株建立大鼠肝癌模型,采用立体定向放射技术,对皮下癌结节取不同的放射剂量一次性照射,观察照射前后肿瘤大小,流式细胞仪检测BCL-2、凋亡率、细胞周期.结果立体定向放射治疗24小时后,肿瘤体积缩小,并与放射剂量呈正相关,随照射剂量的增大凋亡发生率、BCL-2表达率增加,流式细胞仪检测结果显示肿瘤细胞G2期受阻滞.结论立体定向放射治疗肝癌疗效确切,疗效与剂量呈正相关.
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| 关 键 词： | 立体定向 放射治疗 肝癌 |
| 修稿时间： | 2003年3月26日 |
Experimental observation on the effect of gamma-ray stereotactic radio therapy on hepatocellular carcinoma in rats |
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| DING Tiangui,YIN Lijie,PENG Zhaoxiang. Dalian central hospital Dalian ,China.Experimental observation on the effect of gamma-ray stereotactic radio therapy on hepatocellular carcinoma in rats[J].Journal of Practical Oncology,2003,17(2):88-89. |
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| Authors: | DING Tiangui YIN Lijie PENG Zhaoxiang Dalian central hospital Dalian China |
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| Institution: | DING Tiangui,YIN Lijie,PENG Zhaoxiang. Dalian central hospital Dalian 116033,China |
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| Abstract: | Objective To evaluate the radiological effects on experimental hepatocellular carcinoma by using gamma-ray stereotactic radiotherapy. Methods The model of hepatoceliuJar carcinoma was found in rats, the tumor was treated by stereotactic radiotherapy for a single dose of 16 Gy, 24Gy, 32Gy, 40Gy. Then fetched out and analyzed by flow cytometry after 24 hour of radiotherapy. Results 24 hours after irradiation, the tumor volume for OGy, 16Gy, 24Gy, 32Gy, 40Gy irradiated groups were 1.28cm3, 0.54cm3 , 0.52cm3, 0. 47cm3, 0.28cm3 respectively. Tot, bcl-2 were increased with a dose-dependent manner ( P < 0. 05), Significant differences were seen among all five of them. Conclusion Steteotactic radiotherapy is an optional effective way in treatment of hepathocellular carcinoma. |
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| Keywords: | Hepatocellular carcinoma Stereolactic radiotherapy Primary liver tumor |
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