逐瘀汤改善过敏性紫癜患儿纤维蛋白原30例

目的探讨逐瘀汤改善过敏性紫癜患儿血浆纤维蛋白原的临床疗效。方法采用随机对照研究方法,将60例过敏性紫癜患儿随机分为逐瘀汤治疗组30例和对照组30例,两组病例年龄、性别、病程及病情经统计学处理差异无统计学意义。治疗组服用逐瘀汤,对照组用低分子肝素钠IOOU·kg-1·d-1静脉滴注,疗程10天。观察两组患儿血浆纤维蛋白原的改善情况。结果逐瘀汤治疗组和对照组均能降低血浆纤维蛋白原（P〈0．05）,且改善血浆纤维蛋白原的疗效与对照组相当,无统计学意义（P〉0．05）。患儿在试验期间均未发现皮肤黏膜出血等不良反应。结论逐瘀汤能改善过敏性紫癜患儿的高凝状态,且安全,无出血的不良反应。

Effects of Improve the Fibrinogen in 30 Children with Henoch-Schonlein Purpura by Zhuyu Tang

Objective To investigate the effects of improved fibrinogen in children with Henoch-Schonlein purpura by Zhuyu Tang(HSP) . Methods sixty paitents with HSP were divided randomly into Zhuyu Tang treatment group(30 cases) and control group(30 cases) ,there were not significant differences between two groups in age,sexes,course and diseases condition. Zhuyu Tang treatment group received Zhuyu Tang by orally for 10d. Low Molecular Weigh Heparin Sodium(LMWH) group received LMWH by intravenously(100u·kg-1 ·d-1) for 10d. The results of fibrinogen test were compared between two groups. ResuIts Zhuyu Tang and LMWH both could lower fibrinogen(P < 0. 05) . There was no remarkable difference between Zhuyu Tang group and control group(P > 0. 05) . Side effects such as skin and mucosa bleeding did not appeare in both treatment and control groups. Conclusion Zhuyu Tang can reduce fibrinogen of HSP. Zhuyu Tang treatment is safety and effective.