Graduate Division of Biomedical Sciences,1 Departments of Medicine,2 Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York,3 Department of Medicine, New York University School of Medicine, New York, New York4
Abstract:
The ability to utilize serum or plasma samples interchangeably is useful for tuberculosis (TB) serology. We demonstrate a strong correlation between antibody titers to several mycobacterial antigens in serum versus plasma from HIV-infected and non-HIV-infected TB and non-TB patients (r = 0.99 to 0.89; P < 0.0001). Plasma and serum can be used interchangeably in the same antibody detection assays.