基于内质网应激的抗肿瘤药物研发

在缺氧、钙代谢紊乱、氧化应激等条件下,细胞内质网功能受到干扰,未折叠或错误折叠蛋白积聚,将产生内质网应激(endoplasmic reticulum stress,ERS)效应。早期ERS可促使肿瘤细胞存活,但长时间或严重的ERS可诱导肿瘤细胞产生凋亡等效应,这使得基于ERS的抗肿瘤药物研发成为可能。该文主要介绍当前基于ERS的抗肿瘤药物研发概况,总结具有诱导ERS效应的天然产物,并在此基础上对基于ERS的抗肿瘤药物研发进行分析,以期为相关领域的发展提供参考。

Anti-cancer drug research and development based on endoplasmic reticulum stress

A number of physiologic or pathologic stimuli,such as hypoxia,calcium depletion or oxidative stress,may interrupt the function of endoplasmic reticulum and subsequently cause accumulation of unfolded or misfolded proteins which results in endoplasmic reticulum stress(ERS).ERS maintains cancer cell survival initially,but it may eventually trigger apoptosis etc.if endoplasmic reticulum dysfunction is severe or prolonged.Therefore,the drug research and development based on ERS might be a promising strategy for cancer therapy.Herein,the article introduces the progress of anti-cancer drug discovery based on ERS,summarizes some ERS inducers from natural products and analyzes the problems,as well as the prospect in this area.