去势雌性大鼠骨质疏松症的药物干预疗效的评价

目的：评价阿仑膦酸钠、埃本膦酸钠和泰舒对去势雌性大鼠骨质疏松症的治疗效果。方法：手术切除雌性大鼠卵巢制成骨质疏松模型，随机分为4组，即阿仑膦酸钠组、埃本膦酸钠组、泰舒组和对照组，分别给予相应干预药物持续处理6个月。治疗模型给药前、给药后2个月和6个月，分别测定全身骨密度。治疗结束后，进行股骨干重、灰重、骨矿含量、骨生物力学 和骨组织形态计量学测定。结果：阿仑膦酸盐和埃本膦 钠组治疗后6个月后全身骨密度有明显升高，分别增高6．49％和7％；而泰舒组仅上升1．7％，对照组几无变化。埃本膦酸盐治疗后大鼠全身、腰椎骨密度及股骨干重、灰重、最大抗弯曲载荷和骨小梁面积均较其他组高。结论；埃本膦酸钠是比阿仑膦酸钠更有效的一种骨质疏松症治疗药物。

Evaluation of therapeutic effect of drug intervention on osteoporosis in ovariectomized rats

Objective To evaluate the therapeutic effect of alendronate, ibandronate and Taishu on osteoporosis in ovariectomized rats. Methods Osteoporotic rat models were established by ovariectomy. The rats were divided into four groups randomly:alendronate, ibandronate, Taishu,a preparation of chlorotrianisene,and control groups. The treatment groups were fed with the above drugs for consecutive six months. The whole body bone mineral density(BMD) was measured three times during the treatment. After the treatment was finished, the dry weight, ash weight, calcium and phosphorus contents of femoral bone were measured, and histomorphometry of lumbar spine and tibia was performed. Results The whole body BMD after the treatment with alendronate and ibandronate increased by 6 49% and 7%, respectively, while the increasing rate in Taishu group was 1 7%, and no increase was found in the control group. The dry weight, ash weight, calcium and phosphorus contents of the femoral bone, and the trabecula area in ibandronate group were all higher than in other groups. Conclusion Ibandronate, which is better than alendronate, has therapeutic effect on osteoporosis.