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| SerpinE2在细胞外基质代谢中作用的研究进展 | |
| 引用本文： | 冯莹,刘潇,鄂晓强,李雪连. SerpinE2在细胞外基质代谢中作用的研究进展[J]. 中国病理生理杂志, 2018, 34(1): 173-177. DOI: 10.3969/j.issn.1000-4718.2018.01.030 |
| 作者姓名： | 冯莹 刘潇 鄂晓强 李雪连 |
| 作者单位： | 1. 药学院药理教研室, 心血管药物研究教育部重点实验室, 黑龙江 哈尔滨 150001; 2. 附属第一医院骨外科, 黑龙江 哈尔滨 150001 |
| 基金项目： | 国家自然科学基金资助项目（No.81301530） |
| 摘 要： | 正丝氨酸蛋白酶抑制剂E2(serpin peptidase inhibitor clade E member 2,Serpin E2),又称蛋白酶连结蛋白-1(protease nexin-1,PN-1),最初被鉴定为神经胶质源性连接蛋白~([1])。Serpin E2是丝氨酸蛋白酶抑制剂超家族的一员,可以抑制凝血酶、尿激酶、纤溶酶和胰蛋白酶等蛋白酶活性。Serpin E2由人染色体2q99~q35上的SERPINE2基因编码~([2]),是一类可以分泌到细胞外基质(extracellular matrix,ECM)的蛋白 |
| 关 键 词： | 丝氨酸蛋白酶抑制剂E2 细胞外基质 肿瘤 纤维化 |
| 收稿时间： | 2017-06-13 |
Effect of SerpinE2 on metabolism of extracellular matrix |
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| FENG Ying,LIU Xiao,E Xiao-qiang,LI Xue-lian. Effect of SerpinE2 on metabolism of extracellular matrix[J]. Chinese Journal of Pathophysiology, 2018, 34(1): 173-177. DOI: 10.3969/j.issn.1000-4718.2018.01.030 | |
| Authors: | FENG Ying LIU Xiao E Xiao-qiang LI Xue-lian |
| Affiliation: | 1. Department of Pharmacology, College of Pharmacy, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin 150001, China; 2. Department of Orthopaedics, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China |
| Abstract: | Serpin peptidase inhibitor clade E member 2 (SerpinE2), a member of serine peptidase inhibitor super family, regulates multiple serine proteases. Extracellular matrix (ECM) plays an important role in stem cell differentiation, signal transduction, tumor metastasis, osteoarthritis physiological and pathological processes and so on. SerpinE2 regulates the protein of extracellular matrix by serine protease system and matrix metalloproteinase (MMP) system. In this paper, we elaborate the effect of SerpinE2 on metabolism of extracellular matrix, and it will provide new ideas to find new therapeutic targets. |
| Keywords: | Serine peptidase inhibitor clade E member 2 Extracellular matrix Tumour Fibrosis |
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