黄连的化学成分及药理作用研究进展

黄连为常用中药,主要含有异喹啉类生物碱、木脂素、香豆素、黄酮、萜类、甾体、有机酸、挥发油、多糖等多种化学成分,具有降血糖、抗菌、抗氧化、消炎、抗肿瘤、调血脂、抗心律失常等药理活性。显著的降糖活性使黄连较早就用于糖尿病的治疗。对近年来有关黄连的化学成分、降糖作用及其他药理活性进行综述,以期为其深度开发与合理利用提供参考。

Research progress on chemical constituents of Coptidis Rhizoma and its pharmacological activities

As a commonly used Chinese materia medica, Coptis Rhizoma mainly contains isoquinoline alkaloids, lignans, coumarins, flavonoids, terpenes, steroids, organic acids, volatile oil, polysaccharides and other chemical compositions. Its pharmacological activities are hypoglycemic effect, antibacterial, anti-oxidation, anti-inflammatory, antitumor, hypoglycemic, lipid-lowering, anti-arrhythmic activities and so on. The significantly hypoglycemic activity has led to its earlier use in the treatment of diabetes. In this paper, the chemical constituents, hypoglycemic effects, and other pharmacological activities of Coptis Rhizoma in recent years are reviewed in order to provide a reference for the further development and rational utilization of this plant resource.