| 夏天无与延胡索的比较分析及其质量标志物预测 |
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| 引用本文： | 张笑敏,许浚,许姗姗,李冲冲,张铁军,刘昌孝.夏天无与延胡索的比较分析及其质量标志物预测[J].中草药,2018,49(8):1733-1745. |
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| 作者姓名： | 张笑敏 许浚 许姗姗 李冲冲 张铁军 刘昌孝 |
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| 作者单位： | 天津中医药大学中药学院;天津药物研究院天津市中药质量控制技术工程实验室中药质量标志物研究中心;释药技术与药物代谢动力学国家重点实验室实验室天津药物研究院 |
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| 基金项目： | 国家中药标准化项目（ZYBZH-Y-JX-27）；国家自然科学基金重点资助项目（81430096） |
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| 摘 要： | 夏天无与延胡索药材的源植物同为紫堇属植物,均收载于《中国药典》2015年版一部,性味功效相近,但实际临床应用侧重点有所不同。通过查阅文献,从传统功效、化学成分、药理作用等方面比较分析夏天无与延胡索的异同;并基于质量标志物(Q-marker)的核心概念,从生源途径、药效、药动学和体内过程以及传统药性药效等方面对夏天无质量标志物进行预测分析,为建立和完善其药材质量标准提供理论依据。
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| 关 键 词： | 夏天无 延胡索 紫堇属 生物碱 差异分析 质量标志物 |
| 收稿时间： | 2018/3/14 0:00:00 |
Comparative analysis of Corydalis Decumbentis Rhizoma and Corydalis Rhizoma and predictive analysis on Q-marker of Corydalis Decumbentis Rhizoma |
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| ZHANG Xiao-min,XU Jun,XU Shan-shan,ZHANG Tie-jun,LIU Chang-xiao.Comparative analysis of Corydalis Decumbentis Rhizoma and Corydalis Rhizoma and predictive analysis on Q-marker of Corydalis Decumbentis Rhizoma[J].Chinese Traditional and Herbal Drugs,2018,49(8):1733-1745. |
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| Authors: | ZHANG Xiao-min XU Jun XU Shan-shan ZHANG Tie-jun LIU Chang-xiao |
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| Institution: | College of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,College of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research Center of Traditional Chinese Medicine Quality Markers, Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,College of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,College of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Research Center of Traditional Chinese Medicine Quality Markers, Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Center for New Drug Evaluation and Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China and Research Center of Traditional Chinese Medicine Quality Markers, Tianjin Engineering Laboratory of Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Center for New Drug Evaluation and Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | Chinese Pharmacopoeia (2015 edition) recorded that Corydalis Rhizoma and Corydalis Decumbentis Rhizoma are derived from the genus Corydalis, sexual taste similar efficacy, but the actual clinical application of the focus is different. In this paper, the research progress of the two kinds of Chinese materia medica (CMM) is summarized from the three aspects of herbal research, chemical composition, and pharmacological action, which can provide reference for the identification and clinical application of the two drugs. Based on the core concepts of Q-marker, Q-marker components of Corydalis Decumbentis Rhizoma are forecasted and analyzed from original source, efficacy, pharmacokinetics, in vivo process, and the traditional drug property, which provides a theoretical basis for the establishment and improvement of the quality standard of medicinal materials. |
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| Keywords: | Corydalis Decumbentis Rhizoma Corydalis Rhizoma Corydalis DC alkaloid ariance analysis Q-marker |
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