| 鬼箭羽中的1个新西松烷型二萜 |
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| 引用本文： | 赫军,续洁琨,杨弋帆,叶贤胜,张佳,马秉智,张维库. 鬼箭羽中的1个新西松烷型二萜[J]. 中草药, 2018, 49(18): 4212-4215 |
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| 作者姓名： | 赫军 续洁琨 杨弋帆 叶贤胜 张佳 马秉智 张维库 |
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| 作者单位： | 中日友好医院药学部;北京中医药大学生命科学学院;咸阳彩虹学校;中日友好医院临床医学研究所 |
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| 基金项目： | 北京市科委G20工程创新研究项目（Z181100002218029，Z171100001717009）；国家自然科学基金项目（81872761，81473590，81473119） |
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| 摘 要： | 目的研究鬼箭羽(卫矛Euonymus alatus带栓翅的枝条)中的化学成分。方法采用多种柱色谱技术对鬼箭羽95%乙醇提取物进行分离纯化,根据理化性质和波谱数据进行结构鉴定。结果从鬼箭羽提取物中分离得到了3个化合物,分别鉴定为(1S,2S,7E,11R,12S)-2,11-dihydroxy-1,12-oxidocembra-4(18),7(8)-diene(1)、hemerocallal A(2)、桦木酸甲酯(3)。结论化合物1为新的西松烷型二萜,命名为鬼箭羽二萜A,化合物2和3为首次从鬼箭羽中分离得到。
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| 关 键 词： | 鬼箭羽 西松烷二萜 鬼箭羽二萜A hemerocallal A 桦木酸甲酯 |
| 收稿时间： | 2018-06-01 |
A new cembranoid diterpene from twigs of Euonymus alatus |
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| HE Jun,XU Jie-kun,YANG Yi-fan,YE Xian-sheng,ZHANG Ji,MA Bing-zhi and ZHANG Wei-ku. A new cembranoid diterpene from twigs of Euonymus alatus[J]. Chinese Traditional and Herbal Drugs, 2018, 49(18): 4212-4215 |
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| Authors: | HE Jun XU Jie-kun YANG Yi-fan YE Xian-sheng ZHANG Ji MA Bing-zhi ZHANG Wei-ku |
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| Affiliation: | Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China,School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China,Xianyang Rainbow School, Xianyang 712021, China,School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China;Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China,School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China;Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China,Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China and Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China |
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| Abstract: | Objective To study the chemical constituents from the twigs of Euonymus alatus. Methods Compounds were isolated and purified by a combination of various chromatographic techniques, and their structures were elucidated by physiochemical property and spectral analysis. Results Three compounds were obtained from 95% ethanol extract of the twigs of E. alatus and identified as (1S,2S,7E,11R,12S)-2,11-dihydroxy-1,12-oxidocembra-4(18),7(8)-diene (1), hemerocallal A (2), and betulinic acid methyl ester (3). Conclusion Compound 1 is a new cembranoid diterpene and named euonymuditerpene A, and compounds 2 and 3 are isolated from the twigs of Euonymus alatus for the first time. |
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| Keywords: | twigs of Euonymus alatus cembranoid diterpene euonymuditerpene A hemerocallal A betulinic acid methyl ester |
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