| 蛇足石杉内生真菌Penicillium chrysogenum MT-12中2个新二苯醚类成分 |
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| 引用本文： | 张鑫,齐博文,杨洪芸,江芳芳,丁宁,吴云,刘晓,屠鹏飞,史社坡.蛇足石杉内生真菌Penicillium chrysogenum MT-12中2个新二苯醚类成分[J].中草药,2018,49(11):2496-2501. |
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| 作者姓名： | 张鑫 齐博文 杨洪芸 江芳芳 丁宁 吴云 刘晓 屠鹏飞 史社坡 |
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| 作者单位： | 北京中医药大学中药学院中药现代研究中心 |
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| 基金项目： | 国家自然科学基金资助项目（81573312） |
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| 摘 要： | 目的研究蛇足石杉内生真菌Penicillium chrysogenum MT-12经固体发酵培养后的代谢产物。方法利用硅胶、Sephadex LH-20及半制备液相色谱等方法进行分离纯化,根据化合物的理化性质及IR、MS、NMR等光谱数据鉴定化合物的结构;利用体外模型进行抗炎、乙酰胆碱酯酶抑制活性筛选。结果从P.chrysogenum MT-12固体发酵培养后的代谢产物中共分离鉴定8个二苯醚类化合物,分别为黄青霉内酯A(1)、黄青霉内酯B(2)、talaromyone A(3)、isopenicillide(4)、penicillide(5)、hydroxypenicillide(6)、purpactin A(7)、黄青霉内酯C(8)。结论化合物1、2为新化合物,化合物3为首次从青霉属中分离得到,化合物4~8为首次从产黄青霉菌中分离得到;化合物1、2对脂多糖(LPS)诱导的小鼠巨噬细胞RAW264.7的NO产生有一定抑制活性,半数抑制浓度(IC50)值分别为(72.6±2.3)、(41.2±1.4)μmol/L,而所有化合物在100μmol/L时对乙酰胆碱酯酶不显示抑制活性。
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| 关 键 词： | 蛇足石杉 内生真菌 产黄青霉菌 二苯醚类成分 一氧化氮抑制活性 黄青霉内酯A 黄青霉内酯B |
| 收稿时间： | 2018/3/21 0:00:00 |
Two new diphenyl ether derivatives from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata |
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| ZHANG Xin,QI Bo-wen,YANG Hong-yun,JIANG Fang-fang,DING Ning,WU Yun,LIU Xiao,TU Peng-fei and SHI She-po.Two new diphenyl ether derivatives from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata[J].Chinese Traditional and Herbal Drugs,2018,49(11):2496-2501. |
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| Authors: | ZHANG Xin QI Bo-wen YANG Hong-yun JIANG Fang-fang DING Ning WU Yun LIU Xiao TU Peng-fei and SHI She-po |
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| Institution: | Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese;Medicine, Beijing 100029, China,Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese;Medicine, Beijing 100029, China,Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese;Medicine, Beijing 100029, China,Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese;Medicine, Beijing 100029, China,Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese;Medicine, Beijing 100029, China,Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese;Medicine, Beijing 100029, China,Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese;Medicine, Beijing 100029, China,Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese;Medicine, Beijing 100029, China and Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese;Medicine, Beijing 100029, China |
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| Abstract: | |
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| Keywords: | Huperzia serrata(Thunb ex Murray) Trev endophytic fungi Penicillium chrysogenum MT-12 diphenyl ether derivatives inhibitory activity against nitric oxide production penicichrysogenillide A penicichrysogenillide B |
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