肝再生磷酸酶3在恶性血液病中的研究进展

正肝再生磷酸酶3(phosphatase of regenerating liver-3,PRL-3)是蛋白酪氨酸磷酸酶家族的一员。蛋白酪氨酸磷酸酶家族有107个成员,它们通过将底物去磷酸化从而参与某些信号通路,被认为在肿瘤的发生和发展过程中发挥了一定的作用。2001年,Saha等~(1])通过基因表达系列分析(serial analysis of gene expression,SAGE)的方法发现,相对于原发病

Advances of phosphatase of regenerating liver-3 in hematological malignancies

In recent years,accumulating evidence shows that phosphatase of regenerating liver-3(PRL-3) is closely implicated in tumor progression,especially in the stages of invasion and metastasis of various solid tumors,including colorectal cancer,gastric cancer and breast cancer.However,the study of PRL-3 in hematological malignancies is relatively lagged, but there are some advances in leukemia and myeloma,in which PRL-3 up-regulation is tightly associated with poor prognosis,while the underlying mechanism of signal transduction is gradually explored.In this review,we summarized the recent advances of PRL-3 in hematological malignancies such as acute myeloid leukemia,multiple myeloma and chronic myeloid leukemia,as well as the molecular mechanism of PRL-3 in pathogenesis.