Wnt/β-catenin通路与NF-κB通路互相调控在创面愈合中的作用

正Wnt/β-catenin信号通路和核因子κB(nuclear factor kappa B,NF-κB)信号通路都是相对保守的信号通路,贯穿哺乳类动物的一生并可以调节很多生物学进程。研究显示,Wnt/β-catenin通路与NF-κB通路之间存在交互作用,且共同参与多方面的调控。创面愈合是一个复杂而有序的过程,是涉及炎性细胞、细胞外基质和细胞因子等多种因素的级联反应。

Crosstalk between Wnt/β-catenin and NF-κB signaling #br#pathways during wound healing

Both Wnt/β-catenin and NF-κB signaling pathways are conserved pathways that regulate a variety of biological processes throughout the development and adult lifetime of mammals. Recent findings suggest that the 2 signaling pathways can cross-regulate each other. Several studies show that there are both positive and negative regulations between the 2 pathways. Some major components are involved in the cross-regulation of the 2 pathways such as Wnt proteins, DKK1, E-cadherin, GSK-3β, IKKs/IκB and so on. By reviewing the literature, we conjecture that the crosstalk between the 2 pathways regulate the wound healing process by intervening in the inflammation, fibroblast and angiogenesis, but the concrete mechanism is still unknown.