龙须藤多甲氧基总黄酮对小鼠的急性毒性及抗胃溃疡作用研究

目的对龙须藤多甲氧基总黄酮(PMFBC)的小鼠急性毒性及抗胃溃疡作用进行评价。方法以Bliss法测定PMFBC的半数致死量(LD50),评价其急性毒性;采用吲哚美辛、乙醇、水浸应激3种胃溃疡模型评价PMFBC对小鼠急性胃溃疡的保护作用。结果 PMFBC ig给药对小鼠的LD50值为1 256.319 mg/kg,表现出一定的急性毒性;PMFBC对3种胃溃疡模型均有较好的保护作用,可使小鼠胃溃疡面积明显减小,具有较高的溃疡抑制率。结论 PMFBC对小鼠胃溃疡的形成具有明显抑制作用,在一定剂量范围内可安全使用。

Acute toxicity of total polymethoxyflavones from Bauhinia championii in mice and its effects on gastric ulcer

Objective To study the acute toxicity of total polymethoxyflavones from Bauhinia championii (PMFBC) in mice and its effect on experimental gastric ulcer. Methods The acute toxicity of PMFBC was investigated by Bliss method. Three kinds of gastric ulcer model including indomethacin, ethanol, and water immersion-restraint stress were used to observe the effect of PMFBC in mice. Results The LD₅₀ value of ig administration PMFBC on mice was 1 252.319 mg/kg, which showed acute toxicity; PMFBC had protective effect on three gastric ulcer models, which could significantly reduce the ulcer area of the mice, and had a high inhibition rate. Conclusion PMFBC has obvious inhibition effect on the fomation of gastric ulcer in mice, which can be safty used in a certain dose range.