| 基于CRITIC-AHP权重分析法结合Box-Behnken设计-响应面法优选陈皮饮片炮制工艺 |
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| 引用本文： | 张琳,周欣,闫丹,江敏瑜,毛婵,张传辉,王云红,赵凤平,杨荣平. 基于CRITIC-AHP权重分析法结合Box-Behnken设计-响应面法优选陈皮饮片炮制工艺[J]. 中草药, 2018, 49(16): 3829-3834 |
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| 作者姓名： | 张琳 周欣 闫丹 江敏瑜 毛婵 张传辉 王云红 赵凤平 杨荣平 |
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| 作者单位： | 成都中医药大学药学院;西南大学药学院;重庆市中药研究院;重庆市食品药品检验检测研究院 |
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| 摘 要： | 目的优选陈皮饮片炮制工艺。方法采用HPLC法同时测定芸香柚皮苷、橙皮苷、川陈皮素、3,5,6,7,8,3′,4′-七甲氧基黄酮、桔皮素,以层次分析法(CRITIC-AHP)计算权重系数,多指标综合评分结合Box-Behnken设计-响应面法考察加水量、闷润时间、闷润温度对陈皮饮片质量的影响,优选陈皮炮制工艺。结果最佳炮制工艺为每千克陈皮加水量33%,闷润64 min,闷润温度45℃。结论优选的炮制工艺简单可行,为规范陈皮饮片的炮制工艺提供参考,建立的同时测定陈皮中5种黄酮类成分的方法快速可靠,可用于陈皮饮片的质量控制。
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| 关 键 词： | 陈皮饮片 CRITIC法 AHP法 Box-Behnken设计-响应面法 炮制工艺 黄酮类成分 芸香柚皮苷 橙皮苷 川陈皮素 3, 5, 6, 7, 8, 3'', 4''-七甲氧基黄酮 桔皮素 |
| 收稿时间： | 2018-03-19 |
Optimization of processing technology of decoction pieces of Citri Reticulatae Pericarpium by Box-Behnken response surface methodology based on CRITIC-AHP weighted evaluation |
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| ZHANG Lin,ZHOU Xin,YAN Dan,JIANG Min-yu,MAO Chan,ZHANG Chuan-hui,WANG Yun-hong,ZHAO Feng-ping and YANG Rong-ping. Optimization of processing technology of decoction pieces of Citri Reticulatae Pericarpium by Box-Behnken response surface methodology based on CRITIC-AHP weighted evaluation[J]. Chinese Traditional and Herbal Drugs, 2018, 49(16): 3829-3834 |
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| Authors: | ZHANG Lin ZHOU Xin YAN Dan JIANG Min-yu MAO Chan ZHANG Chuan-hui WANG Yun-hong ZHAO Feng-ping YANG Rong-ping |
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| Affiliation: | College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;College of Pharmacy, Southwest University, Chongqing 400715, China,College of Pharmacy, Southwest University, Chongqing 400715, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,College of Pharmacy, Southwest University, Chongqing 400715, China,Chongqing Academy of Chinese Traditional Materia Medica, Chongqing 400065, China,Chongqing Academy of Chinese Traditional Materia Medica, Chongqing 400065, China,Chongqing Institute for Food and Drug Control, Chongqing 401121, China and College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;College of Pharmacy, Southwest University, Chongqing 400715, China |
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| Abstract: | |
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| Keywords: | decoction pieces of Citri Reticulatae Pericarpium CRITIC method AHP method Box-Behnken response surface methodology processing technology flavonoids narirutin hesperidin nobiletin 3, 5, 6, 7, 8, 3'', 4''-heptamethoxy flavones hesperetin |
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